146096-69-7

Upstream product

• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 545-06-2 trichloroacetonitrile 

Downstream Products

• 4980-70-5 1,3-diphenyl-1-propyne 
• 61692-85-1 1-methyl-4-(3-phenyl-2-propyn-1-yl) benzene 
• 61692-86-2 1-chloro-4-(3-phenylprop-2-yn-1-yl)benzene 
• 4437-24-5 1-phenyl-3-(2-furyl)prop-1-yne 
• 1448668-18-5 C₃₀H₂₉NO₄ 

Relevant academic research and scientific papers

Silver-catalysed intramolecular hydroamination of alkynes with trichloroacetimidates

Silver(i) complexes catalyse the intramolecular addition of trichloroacetimidates to alkynes. In the absence of a ligand, the selectivity of the reaction is dependent upon the nature of the counter-anion and solvent. The introduction of non-chelating nitrogeneous ligands suppresses competitive Bronsted acid catalysis, improving the yield and selectivity of the reaction.

HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE

The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

Lewis acid catalyzed propargylation of arenes with O-propargyl trichloroacetimidates: Synthesis of 1,3-diarylpropynes

(Chemical Equation Presented) The BF3·OEt 2-catalyzed Friedel-Crafts propargylation of aromatic compounds with O-propargyl trichloroacetimidates is highly efficient and affords 1,3-diarylpropyne derivatives in good yields.