146097-50-9

Upstream product

• 766-90-5 cis-1-phenyl-1-propylene 
• 146097-56-5 (2R,5R)-2,5-dimethyl-1-{2-{methyl[(4-methylphenyl)sulfonyl]amino}acetyl}pyrrolidine 
• 2644-99-7 2-(N-methyl-N-(p-toluenesulfonamido))acetic acid 
• 95631-21-3 N-methyl-N-tosylglycinoyl chloride 

Relevant academic research and scientific papers

Enantioselective vicinal bis-acylation of olefins

A two-step sequence for the asymmetric vicinal acylation of olefins by a [2+2+1] strategy is reported. The key reaction is a [2+2] cycloaddition of an olefin to a chiral keteniminium salt derived from N-tosylsarcosinamide. This is followed by a regioselec

Asymmetric vicinal acylation of olefins: A new approach to enantiomerically pure γ-lactones

Amide 3 derived from N-tosylsarcosine and (2R,5R)-dimethylpyrrolidine was converted into keteniminium salt 4 which readily cycloadded to olefins. Hydrolysis of the adducts yielded cyclobutanones which were regiospecifically oxidized to γ-lactones 7. High