146098-99-9Relevant academic research and scientific papers
Method for preparing pentazocine intermediates
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Paragraph 0039; 0040; 0041; 0050; 0051; 0059; 0060, (2018/03/26)
The invention discloses a method for preparing pentazocine intermediates, and belongs to the field of medicine synthesis. The method includes synthesizing chiral intermediates by the aid of simple synthesis processes; carrying out addition and hydrogenation debenzylation to obtain key intermediates (-)-(2S, [2a, 6a, 11S])-1, 2, 3, 4, 5, 6-hexahydrogen-cis-6, 11-dimethyl-2, 6-methylene-3-benzo azocines-8-alcohol. The method has the advantages that the method is low in cost and high in yield and includes simple processes, and the chiral purity of the pentazocine intermediates which are productsprepared by the aid of the method can reach 98%.
A Stereocontrolled Alkylation of Chiral Pyridinium Salts with Grignard Reagents: Synthesis of (+)-Normetazocine and (+)-Nordextrorphan
Genisson, Yves,Marazano, Christian,Das, Bhupesh C.
, p. 2052 - 2057 (2007/10/02)
The synthesis of chiral pyridinium salts 3, bearing lipophilic counteranions, is described.These salts, soluble in THF or toluene, undergo nucleophilic alkylation with benzylic Grignard reagents to give, after reduction of the unstable dihydropyridine int
