(2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

Base Information

Chemical Name:(2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine
CAS No.:146098-99-9
Molecular Formula:C₂₃H₂₉NO
Molecular Weight:335.489
Hs Code.:

Synonyms:(2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

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Chemical Property of (2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

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Technology Process of (2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

There total 3 articles about (2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5703-26-4
4-Methoxyphenylacetaldehyde

: C₁₄H₂₁N

: 146098-99-9
(2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

Guidance literature:: With polyphosphoric acid; at 45 ℃; for 18h; Inert atmosphere;

Reference yield: 40.0%

: 38769-92-5
4-methoxybenzylmagnesium chloride

: (+)-3,4-dimethyl-1-<(1R)-1-phenylethyl>pyridinium dodecylsulfate

: (6R)-3,4-dimethyl-6-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

: (2R)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

: 146098-99-9
(2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

Guidance literature:: With sodium tetrahydroborate; Multistep reaction; 1a.) THF, -78 deg C, 0.5 h, 1b.) 0 deg C, 2 h, 2.) Et₂O, MeOH, water, reflux, 1 h;
DOI:10.1021/jo00060a019

Reference yield:

: 57253-29-9,57253-30-2,41178-84-1
3-bromo-2-methyl-1-methyl-1-propene

: 146098-99-9
(2S)-(-)-3,4-dimethyl-2-<(p-methoxyphenyl)methyl>-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; sodium hydride / mineral oil / 0 - 20 °C

2: polyphosphoric acid / 18 h / 45 °C / Inert atmosphere

With sodium hydride; triethylamine; In mineral oil;