1461-82-1

Basic information

• Product Name: Urea, N'-(4-ethoxyphenyl)-N,N-diethyl-
• CAS NO: 1461-82-1
• Molecular Formula: C13H20N2O2
• Molecular Weight: 236.314
• Mol File: 1461-82-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Urea, N'-(4-ethoxyphenyl)-N,N-diethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N'-(4-ethoxyphenyl)-N,N-diethyl-(1461-82-1)
• EPA Substance Registry System: Urea, N'-(4-ethoxyphenyl)-N,N-diethyl-(1461-82-1)

Safety Data

• Hazardous Substances Data: 1461-82-1(Hazardous Substances Data)

Usage

General Description

Urea, N'-(4-ethoxyphenyl)-N,N-diethyl- is a chemical compound with the formula C13H22N2O2. It is a derivative of urea, a natural component of urine and a common nitrogen-containing compound. The presence of the ethoxyphenyl and diethyl groups in this compound make it a potential candidate for use in pharmaceuticals or organic synthesis. This chemical may have applications in the development of drugs or as a reagent in organic chemistry reactions. It is important to handle this compound with care and follow proper safety precautions when working with it in a laboratory setting.

Upstream product

• 634-95-7 N,N-diethylurea 
• 156-43-4 4-Ethoxyaniline 
• 88-10-8 N,N-diethylcarbamyl chloride 

Downstream Products

• 1783-40-0 N-(4-Aethoxy-phenyl)-N',N'-diaethylformamidin 
• 79881-89-3 3-(3-Acetyl-4-hydroxy-phenyl)-1,1-diethylharnstoff 
• 56980-93-9 celiprolol 
• 85045-98-3 3-<3-Acetyl-4-(3-brom-2-hydroxy-propoxy)-phenyl>-1,1-diethylharnstoff 
• 56980-98-4 N'-(3-acetyl-4-(2,3-epoxypropoxy)phenyl)-N,N-diethylurea 

Relevant articles and documents

Synthesis method of celiprolol drug intermediate 3-(4-enthoxyphenyl)-1,1-diethylurea

A synthesis method of celiprolol drug intermediate 3-(4-enthoxyphenyl)-1,1-diethylurea comprises steps as follows: 0.22 mol of p-phenetidine, 0.45-0.47 mol of sodium hydrogen sulfite and 80-90 ml of tetrahydrofuran are added to a reaction container provided with a stirrer and a dropping funnel, the stirring speed is controlled within 130-160 rpm, the solution temperature is controlled within 35-40 DEG C, 0.25-0.27 mol of N,N-diethylamino formamide is dropwise added, the addition time is controlled within 4-5 h, the solution is stirred continuously to react for 30-35 h, 300-350 ml of a sodium chloride solution is added, the pH of the solution is adjusted to range from 4 to 5 with an oxalic acid, the solution reacts continuously for 4-5 h, solids are separated out, the solution is cooled to the temperature of 10-15 DEG C, filtration, washing with a salt solution, dehydration with a dehydrating agent and recrystallization in hexane are performed, and 3-(4-enthoxyphenyl)-1,1-diethylurea is obtained.

On the Synthesis of Cardioselective β-Adrenergic Receptor Blocking Agent Celiprolol

The synthesis of 3--1,1-diethyl-urea-hydrochloride (celiprolol-HCl, in the following briefly called celiprolol; ST 1396-HCl), as well as some physicochemical properties and spectroscopic data are reported. - Key words: β-Blockers; Celiprolol, cardioselectivity, synthesis; ST 1396-HCl