1461-82-1

Usage

Uses

Used in Pharmaceutical Development:
Urea, N'-(4-ethoxyphenyl)-N,N-diethylis used as a pharmaceutical candidate for its potential role in the development of new drugs. The presence of the ethoxyphenyl and diethyl groups may provide specific biological activities or improve the pharmacokinetic properties of the resulting drug molecules.
Used in Organic Synthesis:
In the field of organic chemistry, Urea, N'-(4-ethoxyphenyl)-N,N-diethylserves as a reagent in various chemical reactions. Its unique structure allows it to participate in a range of synthetic pathways, potentially leading to the creation of novel organic compounds with diverse applications.
Used in Research and Development:
Urea, N'-(4-ethoxyphenyl)-N,N-diethylis also utilized in research and development settings to explore its chemical properties and potential interactions with biological systems. Understanding its behavior in different chemical environments can provide insights into its possible uses and limitations in various applications.
Used in Chemical Education:
Urea, N'-(4-ethoxyphenyl)-N,N-diethylcan be employed as a teaching aid in chemical education to illustrate the concepts of functional group modification and its impact on the properties and reactivity of organic compounds. It can help students understand the importance of structural variations in the design and synthesis of new chemical entities.

Upstream product

• 88-10-8 N,N-diethylcarbamyl chloride 
• 156-43-4 4-Ethoxyaniline 
• 634-95-7 N,N-diethylurea 

Downstream Products

• 56980-98-4 N'-(3-acetyl-4-(2,3-epoxypropoxy)phenyl)-N,N-diethylurea 
• 85045-98-3 3-<3-Acetyl-4-(3-brom-2-hydroxy-propoxy)-phenyl>-1,1-diethylharnstoff 
• 56980-93-9 celiprolol 
• 79881-89-3 3-(3-Acetyl-4-hydroxy-phenyl)-1,1-diethylharnstoff 
• 1783-40-0 N-(4-Aethoxy-phenyl)-N',N'-diaethylformamidin 

Relevant academic research and scientific papers

Synthesis method of celiprolol drug intermediate 3-(4-enthoxyphenyl)-1,1-diethylurea

A synthesis method of celiprolol drug intermediate 3-(4-enthoxyphenyl)-1,1-diethylurea comprises steps as follows: 0.22 mol of p-phenetidine, 0.45-0.47 mol of sodium hydrogen sulfite and 80-90 ml of tetrahydrofuran are added to a reaction container provided with a stirrer and a dropping funnel, the stirring speed is controlled within 130-160 rpm, the solution temperature is controlled within 35-40 DEG C, 0.25-0.27 mol of N,N-diethylamino formamide is dropwise added, the addition time is controlled within 4-5 h, the solution is stirred continuously to react for 30-35 h, 300-350 ml of a sodium chloride solution is added, the pH of the solution is adjusted to range from 4 to 5 with an oxalic acid, the solution reacts continuously for 4-5 h, solids are separated out, the solution is cooled to the temperature of 10-15 DEG C, filtration, washing with a salt solution, dehydration with a dehydrating agent and recrystallization in hexane are performed, and 3-(4-enthoxyphenyl)-1,1-diethylurea is obtained.

Process for the preparation of pure, unsymmetrically disubstituted ureas

Process for the preparation of pure, unsymmetrically disubstituted ureas of the general formula STR1 in which R denotes a phenyl radical which is unsubstituted, or monosubstituted or polysubstituted by halogen atoms or alkyl, alkoxy, aryloxy or trifluoromethyl groups, an oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, benzoxazolyl or benzothiazolyl radical which is unsubstituted, or monosubstituted or polysubstituted by halogen atoms or alkyl, alkoxy or trifluoromethyl groups and R1 and R2 independently of one another denote a hydrogen atom or an alkyl group, where R1 and R2 are not simultaneously hydrogen or R1 and R2 together denote a butylene or pentylene group, by reaction of an N-alkyl- or N,N-dialkylurea with an unsubstituted or substituted arylamine or a heterocyclic amine in the presence of that amine which is already present in the starting material, the respective N-alkyl- or N,N-dialkylurea.

On the Synthesis of Cardioselective β-Adrenergic Receptor Blocking Agent Celiprolol

The synthesis of 3--1,1-diethyl-urea-hydrochloride (celiprolol-HCl, in the following briefly called celiprolol; ST 1396-HCl), as well as some physicochemical properties and spectroscopic data are reported. - Key words: β-Blockers; Celiprolol, cardioselectivity, synthesis; ST 1396-HCl