79881-89-3

Usage

Uses

Used in Pharmaceutical Industry:
Urea, N'-(3-Acetyl-4-hydroxyphenyl)-N,N-diethyl is used as an active ingredient for treating skin conditions such as eczema and psoriasis. Its moisturizing and emollient properties help alleviate dryness, itching, and inflammation associated with these conditions.
Used in Cosmetic Industry:
In the cosmetic industry, Urea, N'-(3-Acetyl-4-hydroxyphenyl)-N,N-diethyl is used as a key ingredient in lotions, creams, and other skincare products. Its ability to retain moisture in the skin contributes to improved skin hydration and overall skin health, making it a popular choice for formulations aimed at maintaining skin suppleness and preventing dryness.

InChI:InChI=1/C13H18N2O3/c1-4-15(5-2)13(18)14-10-6-7-12(17)11(8-10)9(3)16/h6-8,17H,4-5H2,1-3H3,(H,14,18)

Upstream product

• 156-43-4 4-Ethoxyaniline 
• 13871-68-6 p-aminophenyl acetate 
• 830-03-5 4-nitrophenol acetate 
• 100-00-5 4-chlorobenzonitrile 
• 1357457-94-3 4-(3,3-diethylureido)phenyl acetate 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 1461-82-1 3-(4-Ethoxy-phenyl)-1,1-diethylharnstoff 
• 75-36-5 acetyl chloride 

Downstream Products

• 108142-72-9 (S)-3-<3-Acetyl-4-(2,2-dimethyl-1,3-dioxolan-4-yl-methoxy)-phenyl>-1,1-diethylharnstoff 
• 57470-78-7 (+/-)-celiprolol hydrochloride 
• 108142-75-2 (R)-3-<3-Acetyl-4-(oxolanyl-methoxy)-phenyl>-1,1-diethylharnstoff 
• 108142-74-1 (S)-3-<3-Acetyl-4-(2-hydroxy-3-tosyloxy-propoxy)-phenyl>-1,1-diethylharnstoff 
• 108142-73-0 (R)-3-<3-Acetyl-4-(2,3-dihydroxy-propoxy)-phenyl>-1,1-diethylharnstoff 
• 85045-98-3 3-<3-Acetyl-4-(3-brom-2-hydroxy-propoxy)-phenyl>-1,1-diethylharnstoff 
• 56980-93-9 celiprolol 
• 56980-98-4 N'-(3-acetyl-4-(2,3-epoxypropoxy)phenyl)-N,N-diethylurea 

Relevant academic research and scientific papers

An improved synthesis of a b-blocker celiprolol hydrochloride

Celiprolol hydrochloride, a β-blocker drug, has been synthesised from 4-chloronitrobenzene. The route involved hydrolysis of the chloride and acetylation of the phenol, reduction of the nitro group, and acylation of theamine. This was followed by Fries rearrangement of the acetyl group, Williamson etherification with epichlorohydrin, followed by opening of the epoxide ring and salt formation. The overall yield of celipropol was 39.1% on the basis of 4-chloronitrobenzene. The Fries rearrangement was substantially improved. The process is suitable for industrial application because of its convenient and environmentally friendly reaction conditions.

On the Synthesis of Cardioselective β-Adrenergic Receptor Blocking Agent Celiprolol

The synthesis of 3--1,1-diethyl-urea-hydrochloride (celiprolol-HCl, in the following briefly called celiprolol; ST 1396-HCl), as well as some physicochemical properties and spectroscopic data are reported. - Key words: β-Blockers; Celiprolol, cardioselectivity, synthesis; ST 1396-HCl