14613-32-2Relevant academic research and scientific papers
Removal of Alkyl Sulfonates Using DABCO
Corazzata, Kaitlyn,Langston, Alexander,Lee, Elaine C.,Mo, Shunyan,Rose, Peter J.,Snodgrass, Joseph
supporting information, (2021/11/30)
During the route development of a midstage clinical candidate, we were challenged with a presence of alkyl sulfonates, which were identified as potential genotoxic impurities in our active pharmaceutical ingredient (API). As a result, we initiated a development effort to identify a method to remove the alkyl sulfonates that would be amenable for scale-up. Herein, we report our effort toward the development of a general approach using DABCO (1,4-diazabicyclo[2.2.2]octane) to remove alkyl sulfonates that is both efficient and convenient from the bench to scale-up.
Triethylammonium-based protic ionic liquids with sulfonic acids: Phase behavior and electrochemistry
Shmukler,Gruzdev,Kudryakova,Fadeeva, Yu A.,Kolker,Safonova
, p. 139 - 146 (2018/06/26)
Six triethylammonium-based protic ionic liquids (PILs) and two molten salts were synthesized via a proton transfer reaction from sulfonic acid to triethylamine (TEA). The PILs were characterized by 1H NMR, 13C NMR, 1H/15N NMR and FT-IR spectroscopic methods. The phase behavior of the PILs was studied using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The temperature dependences of the PILs electrical conductivity, viscosity, and electrochemical stability window (ECW) were studied. The highest electrical conductivity and ECW values are registered in triethylammonium triflate. The thermal and electrochemical characteristics of the salts obtained in this work have been analyzed in comparison with the literature data by the properties of triethylammonium-based salts with sulfonic acids.
