146137-83-9

Usage

Uses

Used in Organic Synthesis:
2-Fluoro-3-iodobenzaldehyde is employed as a key building block in the synthesis of various organic compounds. Its presence of fluorine and iodine atoms at specific positions on the benzene ring allows for a range of chemical reactions, making it a valuable component in the creation of complex organic molecules.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 2-fluoro-3-iodobenzaldehyde is utilized as a precursor for the development of new drugs. Its unique structure can be modified to create molecules with specific biological activities, contributing to the discovery of novel therapeutic agents.
Used in Agrochemicals:
2-Fluoro-3-iodobenzaldehyde also finds application in the agrochemical sector, where it serves as a starting material for the synthesis of various agrochemicals, including pesticides and herbicides. Its chemical properties enable the development of effective compounds for agricultural use.
Used in Chemical Reactions:
As a reagent, 2-fluoro-3-iodobenzaldehyde is involved in the formation of carbon-carbon bonds, which are crucial for constructing the backbones of many organic molecules. Additionally, it is used in the synthesis of heterocyclic compounds, which are important in various chemical and pharmaceutical applications.

Upstream product

• 348-52-7 1-Fluoro-2-iodobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 307975-02-6 (2-fluoro-3-iodo-phenyl)-methanol 
• 211943-27-0 2-fluoro-3-iodobenzonitrile 
• 394-47-8 2-fluorobenzonitrile 
• 109-72-8 n-butyllithium 
• 108-18-9 diisopropylamine 

Downstream Products

• 347185-53-9 2-fluoro-3-iodobenzaldehyde oxime 
• 347185-54-0 C₇H₄ClFINO 
• 1192744-57-2 N-cyclopropyl-2-fluoro-N'-hydroxy-3-iodobenzimidamide 

Relevant academic research and scientific papers

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

A benzo[b]thiophene-based selective type 4 S1P receptor agonist

S1P receptors (S1PR1-5) are a group of GPCRs activated by a high affinity binding with S1P that have important roles in the regulation of the immune system. A potent S1PR agonist FTY720 is an immunomodulator used to treat multiple sclerosis and several ‘second generation’ drugs are under clinical development. Subtype-selective agonists have been reported for each S1PR isotype, some of which are used as pharmacological tools for functional studies. Here we report the discovery and initial characterization of compound 5c, a benzo[b]thiophene amino carboxylate which exhibits potent and selective agonist activity for S1PR4. Compound 5c has an EC50= 200 nM as an agonist in GTPγ35S binding assay for S1PR4 and exhibits no activity against S1PR1,2,3,5. We confirmed its potent activity and decent S1PR subtype selectivity using biochemical and cellular assays.

BENZOTHIOPHENE DERIVATIVE

[Problem to be Solved] It is intended to provide a compound having PDE10A inhibitory activity and having a novel structure, or an isotope thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. [Solution] The present invention provides a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof.

Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement

Crystallographic structural information was used in the design and synthesis of a number of bioisosteric derivatives to replace the amide moiety in a lead series of p38a inhibitors which showed general hydrolytic instability in human liver preparations. Triazole derivative 13 was found to have moderate bioavailability in the rat and demonstrated potent in-vivo activity in an acute model of inflammation.

New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.

Fluorine as an ortho-directing group in aromatic metalation: A two step preparation of substituted benzo[b] thiophene-2-carboxylates

A simple 2-step synthesis of B-ring substituted benzo[b]thiophene-2-carboxylates from aryl fluorides has been developed. The route involves a selective lithiation ortho to fluorine, followed by formylation, and subsequently, displacement of fluorine with