146138-41-2Relevant academic research and scientific papers
Synthesis and antifungal activity of 1,3-bis<2- or 4-(substituted cinnamoyl or 1-acyl-4,5-dihydro-5-substituted phenyl-1H-pyrazol-3-yl)phenoxy-2-propanols and related compounds
Sangwan, Naresh K,Verma, Braham S,Dhindsa, Kuldip Singh
, p. 590 - 594 (2007/10/02)
Condensation of 1,3-bis(2- or 4-acetylphenoxy or 2-acetyl-3-hydroxyphenoxy)-2-propanol (IIa-c), prepared from 2- or 4-hydroxy- or 2,6-dihydroxyacetophenone (Ia-c) and chloromethyloxirane, with substituted benzaldehydes gives the corresponding 1,3-bis-2-propanols (IIIa-i).Isomerization of the phenols IIIg-i with silica gel in solid phase furnishes the corresponding 1,3-bis(2-aryl-2,3-dihydro-4-oxo-4H-1-benzopyran-5-yloxy)-2-propanols (IVa-c).Condensation of IIIa-i with hydrazine in refluxing formic or acetic acid affords thecorresponding substituted 1,3-bis(2- or 4-(1-acyl-4,5-dihydro-5-substituted phenyl-1H-pyrazol-3-yl)phenoxy>-2-propanols (VIa-r).Alkylation of IIIg-i and VIg,h and VIp with ethylchloroacetate gives the corresponding bisacetic acid esters Va-c and VIIa-c respectively.Some of the tested compounds exhibit in vitro growth inhibitory activity against Curvularia ovoidea and Rhizoctonia solani at concentrations of 25-50 μg/ml.
