146139-71-1

Basic information

• Product Name: 2'-(2,4-difluorophenoxy)-4'-nitromethanesulfonanilide
• CAS NO: 146139-71-1
• Molecular Weight: 344.296
• Mol File: 146139-71-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-(2,4-difluorophenoxy)-4'-nitromethanesulfonanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(2,4-difluorophenoxy)-4'-nitromethanesulfonanilide(146139-71-1)
• EPA Substance Registry System: 2'-(2,4-difluorophenoxy)-4'-nitromethanesulfonanilide(146139-71-1)

Safety Data

• Hazardous Substances Data: 146139-71-1(Hazardous Substances Data)

Upstream product

• 146139-70-0 2'-(2,4-difluorophenoxy)methanesulfonanilide 
• 146139-65-3 2,4-Difluoro-1-(2-nitro-phenoxy)-benzene 
• 187845-72-3 2-(2,4-difluorophenoxy)aniline 
• 88-73-3 2-Chloronitrobenzene 
• 367-27-1 2,4-difluorophenol 

Downstream Products

• 116687-66-2 4'-amino-2'-(2,4-difluorophenoxy)methanesulfonanilide 
• 116686-64-7 2'-(2,4-difluorophenoxy)-4'-mercaptomethanesulfonanilide 

Relevant articles and documents

Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxymethanesulfonanilide derivatives

Various 2'-phenoxymethanesulfonanilide derivatives were synthesized and evaluated for antiinfiammatory and analgesic activities. Some compounds bearing an electron-attracting substituent at the 4'-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4'-cyano-(FK867) and 4'-acetyl-(FK3311) 2'-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development.