187845-72-3

Usage

Chemical structure

Consists of a fluoro-substituted phenyl ring attached to an aniline group via an ether linkage.

Common uses

Used as an intermediate in the synthesis of pharmaceuticals and agricultural chemicals.

Potential applications

May be used in the production of dyes, pigments, and polymers.

Research and industrial interest

Its properties and potential uses make it a subject of interest in various research and industrial applications.

Upstream product

• 367-27-1 2,4-difluorophenol 
• 146139-65-3 2,4-Difluoro-1-(2-nitro-phenoxy)-benzene 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 146139-71-1 2'-(2,4-difluorophenoxy)-4'-nitromethanesulfonanilide 
• 116687-66-2 4'-amino-2'-(2,4-difluorophenoxy)methanesulfonanilide 
• 116686-64-7 2'-(2,4-difluorophenoxy)-4'-mercaptomethanesulfonanilide 
• 146139-70-0 2'-(2,4-difluorophenoxy)methanesulfonanilide 

Relevant academic research and scientific papers

Derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II

Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclooxygenase II STR1

Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxymethanesulfonanilide derivatives

Various 2'-phenoxymethanesulfonanilide derivatives were synthesized and evaluated for antiinfiammatory and analgesic activities. Some compounds bearing an electron-attracting substituent at the 4'-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4'-cyano-(FK867) and 4'-acetyl-(FK3311) 2'-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development.