146233-35-4 Usage
Description
(6-AMINOPYRIDAZIN-3-YL)(PHENYL)METHANONE, also known as APDM, is a pyridazinone class compound with the molecular formula C13H10N2O. It is a promising candidate in pharmaceutical research and drug development, exhibiting potential therapeutic effects in the treatment of neurodegenerative diseases and cancer.
Used in Pharmaceutical Research and Drug Development:
APDM is used as a research compound for its potential therapeutic effects in preclinical studies. Its unique chemical structure and properties make it a valuable candidate for medicinal chemistry research.
Used in Neurodegenerative Disease Treatment:
In the field of neurodegenerative diseases, APDM is used as a potential therapeutic agent for its demonstrated effects in preclinical studies. It may offer new avenues for the treatment and management of such conditions.
Used in Cancer Treatment:
In oncology, APDM is used as a potential anticancer agent, showing promise in preclinical studies. Its application in cancer treatment is an area of ongoing investigation, with the aim of discovering new drug candidates for various types of cancer.
Used in Drug Discovery and Development:
APDM is utilized as a subject of ongoing investigation for its potential applications in drug discovery and development. Its exploration in this field is crucial for identifying new therapeutic agents and advancing the understanding of its mechanisms of action.
Check Digit Verification of cas no
The CAS Registry Mumber 146233-35-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,2,3 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 146233-35:
(8*1)+(7*4)+(6*6)+(5*2)+(4*3)+(3*3)+(2*3)+(1*5)=114
114 % 10 = 4
So 146233-35-4 is a valid CAS Registry Number.
146233-35-4Relevant articles and documents
Imidazo[1,2-b]pyridazines, novel nucleus with potent and broad spectrum activity against human picornaviruses: Design, synthesis, and biological evaluation
Hamdouchi, Chafiq,Sanchez-Martinez, Concha,Gruber, Joseph,Del Prado, Miriam,Lopez, Javier,Rubio, Almudena,Heinz, Beverly A.
, p. 4333 - 4341 (2007/10/03)
A novel structural class of picornavirus inhibitors comprising an imidazo[1,2-b]pyridazine nucleus was discovered. 2-Aminoimidazo[1,2-b]pyridazines (6d, (E/Z)-7b, (E)-7d, (Z)-7d, (E/ Z)-8b, (E)-10b, (E)-13a, (Z)-13a, (E)-13b, (Z)-13b, (E)-13c, and (Z)-13c) were designed and synthesized in an effort to identify potent broad spectrum antirhinoviral agents. A practical synthetic route to this chemical scaffold has been developed. The target compounds were evaluated in a plaque reduction assay and in a cytopathic effect assay. Our preliminary SAR studies highlight the minimum structural features required for antirhinovirus activity. Our data suggest that the nature of the linker between the phenyl and the imidazopyridazine moieties has a significant influence on the activity of these compounds. Oximes are slightly better than vinyl carboxamides at this position. The oximes are the most potent analogues against human rhinovirus 14 (HRV-14), and at the concentrations evaluated, no apparent cellular toxicity is noted. Furthermore, the E geometry appears to be a key element for activity; the Z isomer leads to a considerable loss in potency. Of particular interest, analogue 7b exhibits potent broad-spectrum antirhinoviral and antienteroviral activity when evaluated against a panel of seven additional rhino- and enteroviruses. The chemistry and the biological evaluations are discussed.
