146233-32-1

Basic information

• Product Name: (6-CHLOROPYRIDAZIN-3-YL)(PHENYL)METHANONE
• Synonyms: (6-CHLOROPYRIDAZIN-3-YL)(PHENYL)METHANONE
• CAS NO: 146233-32-1
• Molecular Formula: C₁₁H₇ClN₂O
• Molecular Weight: 218.64
• Product Categories: Pyridazine series
• Mol File: 146233-32-1.mol

Chemical Properties

• Boiling Point: 417.025ºC at 760 mmHg
• Flash Point: 206.009ºC
• Appearance: /
• Density: 1.318g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: 2-8°C
• PKA: -0.98±0.10(Predicted)
• CAS DataBase Reference: (6-CHLOROPYRIDAZIN-3-YL)(PHENYL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (6-CHLOROPYRIDAZIN-3-YL)(PHENYL)METHANONE(146233-32-1)
• EPA Substance Registry System: (6-CHLOROPYRIDAZIN-3-YL)(PHENYL)METHANONE(146233-32-1)

Safety Data

• Hazardous Substances Data: 146233-32-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(6-Chloropyridazin-3-yl)(phenyl)methanone is used as a key intermediate in the development of pharmaceuticals, contributing to the creation of new drugs with potential therapeutic benefits. Its unique structure allows for the design of molecules with specific biological activities, targeting a range of medical conditions.
Used in Agrochemical Production:
In the agrochemical industry, (6-chloropyridazin-3-yl)(phenyl)methanone serves as an essential building block for the synthesis of various agrochemicals. It is utilized in the development of pesticides and other crop protection agents, enhancing agricultural productivity and crop quality.
Used in Organic Compound Preparation:
(6-Chloropyridazin-3-yl)(phenyl)methanone is also employed as a versatile building block in the preparation of other organic compounds. Its chemical properties enable the synthesis of a wide array of organic molecules for use in various applications, including materials science, chemical research, and specialty chemical production.
Used in Research and Development:
This chemical compound is utilized in research and development settings to explore its potential applications and properties. Scientists and researchers leverage (6-chloropyridazin-3-yl)(phenyl)methanone to investigate new chemical reactions, develop innovative synthetic routes, and discover novel compounds with unique characteristics and potential uses.

InChI:InChI=1/C11H7ClN2O/c12-10-7-6-9(13-14-10)11(15)8-4-2-1-3-5-8/h1-7H

Upstream product

• 5096-73-1 6-chloro-pyridazine-3-carboxylic acid 
• 141-30-0 3,6-dichlorpyridazine 
• 140-29-4 phenylacetonitrile 
• 6531-04-0 6-chloro-pyridazine-3-carbonyl chloride 
• 71-43-2 benzene 
• 73535-73-6 2‐(6‐chloropyridazin‐3‐yl)‐2‐phenylacetonitrile 

Downstream Products

• 591734-34-8 2-(2,2,2-trifluoroacetamido)-3-(4-fluorophenyl)-6-[(E)-2-N-methylcarbamoyl-1-phenylvinyl]imidazo[1,2-b]pyridazine 
• 591734-40-6 2-(2,2,2-trifluoroacetamido)-3-(4-fluorophenyl)-6-[(Z)-2-N-methylcarbamoyl-1-phenylvinyl]imidazo[1,2-b]pyridazine 
• 591734-32-6 3-(2'-ethoxycarbonyl-1'-phenylvinyl)-2-(2,2,2-trifluoroacetamido)-3-(4'-fluorophenyl)imidazo[1,2-b]pyridazine 
• 591734-18-8 2-[3-benzoyl-6-(toluene-4-sulfonylimino)-6H-pyridazin-1-yl]-2-(4-fluorophenyl)acetamide 
• 591734-22-4 2,2,2-trifluoro-N-[3-(4-fluorophenyl)-6-benzoylimidazo[1,2-b]pyridazin-2-yl]acetamide 
• 591734-20-2 2-[3-benzoyl-6-(toluene-4-sulfonylimino)-6H-pyridazin-1-yl]-2-phenylacetamide 
• 591734-24-6 2-N-[6-benzoyl-3-phenylimidazo[1,2-b]pyridazin-2-yl]-2,2,2-trifluoroacetamide 
• 591734-25-7 2-amino-3-(4-fluorophenyl)-6-benzoylimidazo[1,2-b]pyridazine 
• 591734-14-4 N-(6-benzoyl)-2H-pyridazin-3-ylidene-4-methylbenzenesulfonamide 
• 591734-26-8 2-amino-3-phenyl-6-benzoylimidazo[1,2-b]pyridazine 
• 146233-35-4 3-amino-6-benzoylpyridazine 

Relevant articles and documents

Imidazo[1,2-b]pyridazines, novel nucleus with potent and broad spectrum activity against human picornaviruses: Design, synthesis, and biological evaluation

A novel structural class of picornavirus inhibitors comprising an imidazo[1,2-b]pyridazine nucleus was discovered. 2-Aminoimidazo[1,2-b]pyridazines (6d, (E/Z)-7b, (E)-7d, (Z)-7d, (E/ Z)-8b, (E)-10b, (E)-13a, (Z)-13a, (E)-13b, (Z)-13b, (E)-13c, and (Z)-13c) were designed and synthesized in an effort to identify potent broad spectrum antirhinoviral agents. A practical synthetic route to this chemical scaffold has been developed. The target compounds were evaluated in a plaque reduction assay and in a cytopathic effect assay. Our preliminary SAR studies highlight the minimum structural features required for antirhinovirus activity. Our data suggest that the nature of the linker between the phenyl and the imidazopyridazine moieties has a significant influence on the activity of these compounds. Oximes are slightly better than vinyl carboxamides at this position. The oximes are the most potent analogues against human rhinovirus 14 (HRV-14), and at the concentrations evaluated, no apparent cellular toxicity is noted. Furthermore, the E geometry appears to be a key element for activity; the Z isomer leads to a considerable loss in potency. Of particular interest, analogue 7b exhibits potent broad-spectrum antirhinoviral and antienteroviral activity when evaluated against a panel of seven additional rhino- and enteroviruses. The chemistry and the biological evaluations are discussed.

Pyridazines. LXVIII. Convenient synthesis of phenyl (6-substituted 3- pyridazinyl) ketones via the oxidative decyanation route

A convenient approach to aryl 3-pyridazinyl ketones 4, 7-10 bearing various O-, N-, or C-substituents at C-6 of the diazine nucleus via oxidative decyanation of appropriate aryl-heteroaryl-acetonitriles is proposed.