146236-47-7Relevant academic research and scientific papers
Total Syntheses of the Metabolites of Schizandrin
Tanaka, Masahide,Ikeya, Yukinobu,Mitsuhashi, Hiroshi,Maruno, Masao,Wakamatsu, Takeshi
, p. 11703 - 11724 (2007/10/02)
The total syntheses of the metabolites of schizandrin were achieved.The tetracyclic lactone intermediates (13a-e) were prepared in optically pure form by the oxidative coupling reaction of the corresponding 3-benzyl-2-benzylidenebutyrolactones.Mukaiyama hydration of 13b afforded hydroxylactone (14), which was converted into SZ-M3 (4).The introduction of C6,7-diol moiety, which is common to the metabolites (4-11), was carried out by the successive double bond migration to 15a-e, lactone ring reduction ot the allylic diols (32a-e), and glycol formation.Then, reduction of the mesylates 33 completed the syntheses of the metabolites.
Process for the preparation of polycyclic compounds using ferric perchlorate and acid trifluoroacidic
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, (2008/06/13)
Polycyclic compounds (I) can be prepared in accordance with the following reaction formula: STR1 wherein R1 -R8 each represents a hydrogen atom, a hydroxyl group, an alkoxyl group or a substituted or unsubstituted benzyloxy group or
Polycyclic compounds, their preparation and their use as phosphodiesterases inhibitors
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, (2008/06/13)
Polycyclic compounds (I) can be prepared in accordance with the following reaction formula: wherein R1-R8 each represents a hydrogen atom, a hydroxyl group, an alkoxyl group or a substituted or unsubstituted benzyloxy group or neighb
