146303-58-4

Basic information

• Product Name: 4-methyl-N-(methoxymethyl)-N-methylaniline
• Synonyms: 4-methyl-N-(methoxymethyl)-N-methylaniline
• CAS NO: 146303-58-4
• Molecular Weight: 165.235
• Mol File: 146303-58-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(methoxymethyl)-N-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(methoxymethyl)-N-methylaniline(146303-58-4)
• EPA Substance Registry System: 4-methyl-N-(methoxymethyl)-N-methylaniline(146303-58-4)

Safety Data

• Hazardous Substances Data: 146303-58-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 623-08-5 N-methyl-p-toluidine 
• 106-47-8 4-chloro-aniline 
• 99-97-8 Dimethyl-p-toluidine 

Downstream Products

• 623-08-5 N-methyl-p-toluidine 

Relevant articles and documents

Oxidative Demethylation of 4-Substituted N,N-Dimethylanilines with Iodine and Calcium Oxide in the Presence of Methanol

Reaction of para-substituted N,N-dimethylarylamines with iodine-calcium oxide in tetrahydrofuran-methanol affords N-methylarylamines in good yield.

Room temperature N-alkylation of amines with alcohols under UV irradiation catalyzed by Cu-Mo/TiO2

It is highly desirable to develop efficient heterogeneous photocatalysts for organic reactions. Here, we show the preparation and catalytic performance of a novel TiO2 (P25) supported Cu and Mo photocatalyst (Cu-Mo/TiO2) for N-alkylation of amines with alcohols under UV irradiation at room temperature. A variety of aromatic and aliphatic amines were selectively converted into the corresponding secondary amines or tertiary amines in moderate to excellent yields without the addition of any co-catalysts such as bases and organic ligands. Noteworthy, this catalytic system is feasible in the alkylation of anilines containing halogen substituents with alcohols and the yields of the desired products are up to 95%.

Ruthenium-catalyzed oxidation of tertiary amines with hydrogen peroxide in the presence of methanol

α-Methoxylation of tertiary amines can be performed by the ruthenium-catalyzed oxidation of tertiary amines with hydrogen peroxide in the presence of methanol. The reaction provides an efficient method for selective N-demethylation of tertiary methylamines and construction of quinoline skeletons.