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14631-48-2

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14631-48-2 Usage

Description

5,6,7,8-Tetrahydro-1-quinoliniumolate, a quinoline derivative with the molecular formula C9H11NO, is a quaternary ammonium salt featuring a quaternary nitrogen atom. This chemical compound is widely utilized in organic synthesis and as a reagent in various chemical reactions. Its potential applications in pharmaceuticals have been the subject of research, with studies indicating its possible anticancer and neuroprotective properties. Additionally, it has garnered interest in the field of materials science for the development of innovative functional materials.

Uses

Used in Pharmaceutical Applications:
5,6,7,8-Tetrahydro-1-quinoliniumolate is used as a pharmaceutical candidate for its potential anticancer properties, as research suggests it may exhibit inhibitory effects on tumor growth and progression. It is also being studied for its neuroprotective capabilities, which could be beneficial in the treatment of neurological disorders.
Used in Organic Synthesis:
In the field of organic synthesis, 5,6,7,8-tetrahydro-1-quinoliniumolate serves as a valuable reagent in chemical reactions, contributing to the synthesis of various organic compounds.
Used in Materials Science:
5,6,7,8-Tetrahydro-1-quinoliniumolate is used in the development of new functional materials, where its unique properties can be harnessed to create innovative materials with specific applications in various industries.
Used in Chemical Reactions as a Reagent:
As a reagent, 5,6,7,8-tetrahydro-1-quinoliniumolate is employed in a variety of chemical reactions to facilitate specific transformations or to enhance the efficiency of the processes involved.

Check Digit Verification of cas no

The CAS Registry Mumber 14631-48-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,6,3 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 14631-48:
(7*1)+(6*4)+(5*6)+(4*3)+(3*1)+(2*4)+(1*8)=92
92 % 10 = 2
So 14631-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO/c11-10-7-3-5-8-4-1-2-6-9(8)10/h3,5,7H,1-2,4,6H2

14631-48-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-oxido-5,6,7,8-tetrahydroquinolin-1-ium

1.2 Other means of identification

Product number -
Other names 2,3-Cyclohexenopyridine N-oxide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14631-48-2 SDS

14631-48-2Relevant articles and documents

Water-soluble inhibitors of ABCG2 (BCRP) – A fragment-based and computational approach

Antoni, Frauke,Wifling, David,Bernhardt, Günther

, (2021)

A good balance between hydrophilicity and lipophilicity is a prerequisite for all bioactive compounds. If the hydrophilicity of a compound is low, its solubility in water will be meager. Many drug development failures have been attributed to poor aqueous solubility. ABCG2 inhibitors are especially prone to be insoluble since they have to address the extremely large and hydrophobic multidrug binding site in ABCG2. For instance, our previous, tariquidar-related ABCG2 inhibitor UR-MB108 (1) showed high potency (79 nM), but very low aqueous solubility (78 nM). To discover novel potent ABCG2 inhibitors with improved solubility we pursued a fragment-based approach. Substructures of 1 were optimized and the fragments ‘enlarged’ to obtain inhibitors, supported by molecular docking studies. Synthesis was achieved, i.a., via Sonogashira coupling, click chemistry and amide coupling. A kinetic solubility assay revealed that 1 and most novel inhibitors did not precipitate during the short time period of the applied biological assays. The solubility of the compounds in aqueous media at equilibrium was investigated in a thermodynamic solubility assay, where UR-Ant116 (40), UR-Ant121 (41), UR-Ant131 (48) and UR-Ant132 (49) excelled with solubilities between 1 μM and 1.5 μM – an up to 19-fold improvement compared to 1. Moreover, these novel N-phenyl-chromone-2-carboxamides inhibited ABCG2 in a Hoechst 33342 transport assay with potencies in the low three-digit nanomolar range, reversed MDR in cancer cells, were non-toxic and proved stable in blood plasma. All properties make them attractive candidates for in vitro assays requiring long-term incubation and in vivo studies, both needing sufficient solubility at equilibrium. 41 and 49 were highly ABCG2-selective, a precondition for developing PET tracers. The triple ABCB1/C1/G2 inhibitor 40 qualifies for potential therapeutic applications, given the concerted role of the three transporter subtypes at many tissue barriers, e.g. the BBB.

Efficient Pyrazolo[5,4-f]quinoxaline Functionalized Os(II) Based Emitter with an Electroluminescence Peak Maximum at 811 nm

Zhu, Ze-Lin,Wang, Sheng-Fu,Fu, Li-Wen,Tan, Ji-Hua,Cao, Chen,Yuan, Yi,Yiu, Shek-Man,Zhang, Ye-Xin,Chi, Yun,Lee, Chun-Sing

supporting information, (2021/12/09)

Upon fusing the pyrazinyl pyrazole entity in giving pyrazolo[3,4-f]quinoxaline chelate, the corresponding Os(II) based NIR emitter exhibited “invisible” and efficient electroluminescence with a peak maximum at 811 nm. A maximum external quantum efficiency

Visible-Light-Induced C2 Alkylation of Pyridine N-Oxides

Zhang, Wen-Man,Dai, Jian-Jun,Xu, Jun,Xu, Hua-Jian

, p. 2059 - 2066 (2017/02/26)

A photoredox catalytic method has been developed for the direct C2 alkylation of pyridine N-oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2-alkylated pyridine N-oxides under mild conditions. Mechanistic studies are consistent with the generation of a radical intermediate along the reaction pathway.

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