146346-88-5 Usage
General Description
Fmoc-Ala-OMe is a chemical compound comprised of Fmoc (Fluorenylmethoxycarbonyl) protecting group, Ala (Alanine) amino acid and OMe (Methyl ester) functional group. It is commonly used in peptide synthesis as a building block for producing peptides with specific sequences. Fmoc is used as a temporary protecting group for the amino group of Ala, allowing for selective deprotection and further chain elongation during peptide synthesis. The OMe group on the Ala residue serves as a protecting group for the carboxyl group, preventing unwanted reactions during synthesis. Overall, Fmoc-Ala-OMe is an important chemical component in the production of custom peptides for research and pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 146346-88-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,3,4 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 146346-88:
(8*1)+(7*4)+(6*6)+(5*3)+(4*4)+(3*6)+(2*8)+(1*8)=145
145 % 10 = 5
So 146346-88-5 is a valid CAS Registry Number.
146346-88-5Relevant articles and documents
Copper catalyzed aryl amidation between Nα-Fmoc-protected amino-acid azides and aryl boronic acids
Kumar, L. Roopesh,Thimmalapura, Vishwanatha,Panduranga, Veladi,Mahesh, Mandipogula,Ramana, P. Venkata,Sureshbabu, Vommina V.
, p. 506 - 515 (2020/01/08)
A simple and efficient method for the synthesis of aryl amides via oxidative copper-catalyzed coupling of commercially available aryl boronic acids and bench stable Nα-protected amino-acid azides is reported. The potential utility of this protocol is demonstrated through a survey of diversely substituted aryl boronic acids and several side-chain functionalized amino-acid azides, leading to the preparation of the desired amidated products in good to excellent yields. This amide synthesis is suitable for the preparation of amides (such as peptide aryl amides and sterically hindered amino acids) that are not or hardly accessible via classical approaches.
