14636-29-4

Upstream product

• 23153-73-3 ethyl 1,4-dioxaspiro[4,4]nonane-6-carboxylate 
• 591-50-4 iodobenzene 
• 308805-77-8 1-(2-phenylethynyl)-1-cyclobutanol 
• 108-86-1 bromobenzene 
• 536-74-3 phenylacetylene 
• 100-58-3 phenylmagnesium bromide 
• 141-28-6 diethyl adipate 
• 32396-37-5 methyl 2-[(bis(N,N-dimethylamino)phosphoryl)oxy]cyclopent-1-ene-1-carboxylate 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 696-62-8 para-iodoanisole 
• 603-35-0 triphenylphosphine 

Downstream Products

• 30614-37-0 2-(diphenylmethyl)cyclopentanone 

Relevant academic research and scientific papers

Palladium-catalyzed ring expansion reaction of 1-alkynylcyclobutanols with aryl iodides: An efficient route to 2-disubstituted methylenecyclopentanones

The reaction of 1-alkynylcyclobutanols with aryl iodides in the presence of Pd(OAc)2 and Et3N in acetonitrile at 80°C for 24 h gives 2-disubstituted methylenecyclopentan-1-ones in modest to good yields. The tandem insertion-ring expansion process proceeds via the formation of an alkynyl π-complex, followed by migration of a carbon-carbon bond of the tert-alkanol to form the cyclopentanones stereoselectively.

Rhodium(I)-catalyzed acylation of alkyne with acylsilane: Transformation of 5- or 6-alkynoylsilane to α-alkylidenecycloalkanone

Rhodium(I)-catalyzed intramolecular acylation of alkynyl group proceeds by the use of acylsilanes having an alkynyl moiety. 5-and 6-Alkynoylsilanes are converted to α-alkylidenecycloalkanones by treatment with [RhCl(CO)2]2 in the presence of acetic acid via transmetallation between the acylsilane moiety and a rhodium(I) complex.

Synthesis of 2-alkylidenecyclopentanones via palladium-catalyzed cross-coupling of 1-(1-alkynyl)cyclobutanols and aryl or vinylic halides

(matrix presented) The palladium-catalyzed cross-coupling of aryl or vinylic halides and 1-(1-alkynyl)cyclobutanols affords good yields of stereoisomerically pure 2-arylidene-or 2-(2-alkenylidene)cyclopentanones, respectively, by a process involving (1) o

Formation of trisubstituted buta-1,3-dienes and α,β-unsaturated ketonesviathe reaction of functionalized vinyl phosphates and vinyl phosphordiamidates with organometallic reagents

We studied the reactions of vinyl phosphates and vinyl phosphordiamidates containing an ester functional group with organometallic reagents. We found that the functionalized vinyl phosphates were smoothly converted into tri- and tetrasubstituted buta-1,3-

2-METHYLENE-5-SUBSTITUTED-METHYLENECYCLOPENTANONE DERIVATIVES AND USE THEREOF

The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.

2-METHYLENE-5-SUBSTITUTED METHYLENE CYCLOPENTANONE DERIVATIVES AND USE THEREOF

The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.

Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl- methylenecyclopentanone hydrochlorides and related compounds

Eleven new diaryl-methylenecyclopentanone Mannich hydrochlorides and related compounds were synthesized with different modification on Mannich base and α,β-unsaturated bonds. The glutathione-binding ability, glutathione-s-transferase π (GSTπ) inhibition a

Synthesis of 2-alkylidenecyclopentanones via palladium-catalyzed carbopalladation/ring expansion of 1-(1-alkynyl)cyclobutanols

The palladium-catalyzed cross-coupling of aryl halides or vinylic halides or triflates and 1-(1-alkynyl)cyclobutanols affords good yields of stereoisomerically pure 2-arylidene- or 2-(2-al-kenylidene)cyclopentanones, respectively. The process involves (1)