23153-73-3Relevant academic research and scientific papers
SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
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Page/Page column 73, (2013/09/12)
The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
2-METHYLENE-5-SUBSTITUTED-METHYLENECYCLOPENTANONE DERIVATIVES AND USE THEREOF
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Page/Page column 12, (2011/04/18)
The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.
2-METHYLENE-5-SUBSTITUTED METHYLENE CYCLOPENTANONE DERIVATIVES AND USE THEREOF
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Page/Page column 17, (2010/11/19)
The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.
Microbiological transformations 60. Enantioconvergent baeyer-villiger oxidation via a combined whole cells and ionic exchange resin-catalysed dynamic kinetic resolution process
Gutierrez, Maria-Concepcion,Furstoss, Roland,Alphand, Veronique
, p. 1051 - 1059 (2007/10/03)
A dynamic kinetic resolution process was applied to an enantioconvergent microbial Baeyer-Villiger oxidation of benzyloxycyclopentanone, rac-1. This was achieved by combining a whole cell-based kinetic resolution and an anion exchange resin-catalysed in s
Synthesis and photoinitiated radical cyclization of allyl- and propynyloxymethyl substituted cyclopentanones to tetrahydrocyclopenta[c]furanols
Tzvetkov, Nikolay T.,Mattay, Jochen
, p. 7751 - 7755 (2007/10/03)
Bicyclic cyclopentafuranols were formed by photoinitiated radical cyclization of allyl- and propinyloxymethyl substituted cyclopentanones with high regioselectivity. The irradiations were carried out at a wavelength of 300 nm in aprotic solvents such as benzene and acetonitrile. We could also show that reductive photoinduced electron transfer (PET) of the propynyloxymethyl substituted cyclopentanone 5 does not lead to any cyclization. The starting materials were synthesized in good yields following known procedures.
Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones
Shcherbakova, Irina,Huang, Guangfei,Geoffroy, Otto J.,Nair, Satheesh K.,Swierczek, Krzysztof,Balandrin, Manuel F.,Fox, John,Heaton, William L.,Conklin, Rebecca L.
, p. 2537 - 2540 (2007/10/03)
Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described.
Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl- methylenecyclopentanone hydrochlorides and related compounds
Wang, Jingli,Zhao, Linxiang,Wang, Rui,Lu, Min,Chen, Duo,Jing, Yongkui
, p. 1285 - 1291 (2007/10/03)
Eleven new diaryl-methylenecyclopentanone Mannich hydrochlorides and related compounds were synthesized with different modification on Mannich base and α,β-unsaturated bonds. The glutathione-binding ability, glutathione-s-transferase π (GSTπ) inhibition a
Cathodic cyclisation of N-(oxoalkyl)pyridinium salts - Formation of tricyclic indolizidine and quinolizidine derivatives in aqueous medium
Heimann, Jens,Schaefer, Hans J.,Froehlich, Roland,Wibbeling, Birgit
, p. 2919 - 2932 (2007/10/03)
The cathodic cyclisation of N-(oxoalkyl)pyridinium salts, derived from 4-methylpyridine and cyclic ketones, afforded functionalised tricyclic indolizidine and quinolizidine derivatives in high yields. Through systematic variation of the ring size of the k
Highly efficient heterogeneous acetalization of carbonyl compounds catalyzed by a titanium cation-exchanged montmorillonite
Kawabata, Tomonori,Mizugaki, Tomoo,Ebitani, Kohki,Kaneda, Kiyotomi
, p. 8329 - 8332 (2007/10/03)
The titanium cation-exchanged montmorillonite efficiently catalyzed the selective acetalization of various carbonyl compounds as a recyclable solid acid. This heterogeneous catalyst has an advantage of a strikingly simple workup procedure over conventional homogeneous acids.
Facile synthesis of unsaturated lactones via intramolecular Wittig reaction
Kumar, Pradeep,Saravanan
, p. 2161 - 2168 (2007/10/03)
The phosphoranes 3 formed from the reaction of a variety of keto alcohols 1 and (triphenylphosphoranylidene)ethenone 2 undergo intramolecular Wittig cyclization to afford the unsaturated lactones in moderate yields.
