1463609-35-9

Upstream product

• 26673-31-4 6-chloro-3,4-dihydronaphthalen-1(2H)-one 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 1463609-22-4 tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate 
• 1463609-25-7 6-chloro-2-(piperidine-4-carbonyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1463609-29-1 6-chloro-2-(1-phenethylpiperidine-4-carbonyl)-3,4-dihydronaphthalen-1(2H)-one 

Relevant academic research and scientific papers

Synthesis of tricyclic condensed rings incorporating the pyrazole or isoxazole moieties bonded to a 4-piperidinyl substituent

In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.