146368-15-2 Usage
Uses
Used in Biomedical Research:
Cy5-bifunctional dye is used as a fluorescent probe for monitoring molecular interactions and studying biological processes. The application reason is its ability to switch between a bright and dark state upon exposure to light, allowing for precise control and visualization of molecular events in real-time.
Used in Drug Delivery Systems:
Cy5-bifunctional dye is used as a targeting agent for drug delivery systems, particularly in cancer therapy. The application reason is its strong affinity for biopolymers and macromolecules, enabling selective targeting and delivery of therapeutic agents to specific cells or tissues.
Used in Analytical Chemistry:
Cy5-bifunctional dye is used as a detection agent in various analytical techniques, such as fluorescence microscopy and flow cytometry. The application reason is its high sensitivity and specificity, allowing for accurate detection and quantification of target molecules in complex biological samples.
Used in Photodynamic Therapy:
Cy5-bifunctional dye is used as a photosensitizer in photodynamic therapy for cancer treatment. The application reason is its ability to generate reactive oxygen species upon light activation, causing localized cell death and minimizing damage to surrounding healthy tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 146368-15-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,3,6 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 146368-15:
(8*1)+(7*4)+(6*6)+(5*3)+(4*6)+(3*8)+(2*1)+(1*5)=142
142 % 10 = 2
So 146368-15-2 is a valid CAS Registry Number.
InChI:InChI=1/C45H52N4O14S2/c1-44(2)32-28-30(64(56,57)58)18-20-34(32)46(26-12-6-10-16-42(54)62-48-38(50)22-23-39(48)51)36(44)14-8-5-9-15-37-45(3,4)33-29-31(65(59,60)61)19-21-35(33)47(37)27-13-7-11-17-43(55)63-49-40(52)24-25-41(49)53/h5,8-9,14-15,18-21,28-29H,6-7,10-13,16-17,22-27H2,1-4H3,(H-,56,57,58,59,60,61)
146368-15-2Relevant academic research and scientific papers
Novel asymmetric Cy5 dyes: Synthesis, photostabilities and high sensitivity in protein fluorescence labeling
Wang, Li,Fan, Jiangli,Qiao, Xiaoqiang,Peng, Xiaojun,Dai, Bin,Wang, Bingshuai,Sun, Shiguo,Zhang, Lihua,Zhang, Yukui
experimental part, p. 168 - 172 (2010/10/20)
Several novel water-soluble asymmetric pentamethine cyanine dyes were synthesized. The maximum absorption and emission wavelengths of the dyes in different solvents were in the range from 647 to 665 nm and exhibited negative solvatochromism with increasing solvent polarity. The fluorescence quantum yields of the dyes were about 0.1 in water, and were obviously higher than those of hydrophobic cyanine dyes. Dyes with N-benzyl groups and N-sulfo-groups displayed greater photostability than dyes with N-carboxypentyl groups in water. The limit of detection of dye 5a for BSA was 1.2 × 10-8 mol L-1 by high performance liquid chromatography with fluorescent director about 100-fold lower than that by UV detection (1.0 × 10-6 mol L-1). Therefore, Dye 5a could be used to improve photostability and detection sensitivity in protein analysis.
