146368-58-3Relevant academic research and scientific papers
Asymmetric reduction of 2-chloro-3-oxo esters by transfer hydrogenation
Bai, Jinjin,Miao, Shifeng,Wu, Yun,Zhang, Yawen
, p. 2476 - 2480 (2011)
Asymmetric reduction of 2-chloro-3-oxo esters was achieved by catalytic transfer hydrogenation using [RuCl2(p-cymene)](S,S)-TsDPEN as the chiral catalyst and HCOOH-Et3N as the hydrogen source. Moderate to good yields (up to 85%) and
Microbial reduction of 2-chloro-3-aryl-3-oxopropionic acid esters
Cabon,Larcheveque,Buisson,Azerad
, p. 7337 - 7340 (2007/10/02)
2-Chloro-3-aryl-3-oxopropionic acid esters are reduced by microorganisms to syn- and/or anti-2-chloro-3-hydroxy-3-arylpropionates, in competition with dechlorination and decarboxylation reactions. Using selected strains, it is possible to obtain enantiomerically pure chlorohydroxyesters, which were converted to the corresponding phenylglycidic esters with high stereospecificity.
