146374-56-3

Basic information

• Product Name: Ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)acetate
• Synonyms: Ethyl(2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)acetate;ETHYL(2-CYANOIMINO-5,6-DICHLORO-1,2,3,4-TETRA-HYDROQUINAZOLINE-3-YL)ACETATE
• CAS NO: 146374-56-3
• Molecular Formula: C₁₃H₁₂Cl₂N₄O₂
• Molecular Weight: 327.17
• Mol File: 146374-56-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 466.78°C at 760 mmHg
• Flash Point: 236.101°C
• Appearance: /
• Density: 1.464g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: Ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)acetate(146374-56-3)
• EPA Substance Registry System: Ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)acetate(146374-56-3)

Safety Data

• Hazardous Substances Data: 146374-56-3(Hazardous Substances Data)

Usage

General Description

Ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)acetate is a chemical compound with a complex molecular structure. It is an ester derivative of a tetrahydroquinazoline, containing cyanoimino and dichloro groups. Ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)acetate is primarily used in the pharmaceutical industry for the synthesis of other organic compounds, including potential drug candidates. It may also have potential applications in the field of medicinal chemistry and drug development due to its unique structure and properties. However, further research and analysis are needed to fully understand and harness the potential of this chemical.

InChI:InChI=1/C13H12Cl2N4O2/c1-2-21-11(20)6-19-5-8-10(18-13(19)17-7-16)4-3-9(14)12(8)15/h3-4H,2,5-6H2,1H3,(H,17,18)

Upstream product

• 70406-92-7 N-(6-amino-2,3-dichlorobenzyl)glycine ethyl ester 
• 79463-77-7 N-cyanodiphenylcarbonimidate 
• 105-36-2 ethyl bromoacetate 
• 200571-11-5 2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazoline 
• 10191-60-3 dimethyl N-cyanodithioiminocarbonate 
• 24771-25-3 dimethyl (N-cyanoimido)carbonate 
• 31350-31-9 bis(benzylmercapto)methylene cyanamide 
• 200571-09-1 S-methyl-N-cyano-N'-(2-amino-5,6-dichlorobenzyl)isothiourea 

Downstream Products

• 68475-42-3 anagrelide 

Relevant articles and documents

A convenient large-scale synthesis of ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazoline-3-yl)acetate

-

Process for and 2-(cyanoimino)-quinazoline derivatives useful as intermediates in the preparation of 6,7-di-(chloro)-1,5-di(hydro)-imidazo-[2,1-b]quinazolin-2[3H]-one and process for preparing the 2-(cyanoimino)-quinazoline derivatives

A subject matter of the invention is a process for the preparation of 6,7-di-(chloro)-1,5-di-(hydro)-imidazo[2,1-b]quinazolin-2[3H]-one of formula or a salt thereof including their hydrates, characterized by subjecting [2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl]-acetonitrile or a /2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl/-acetic acid alkylester of the general formula wherein R'stands for a cyano group or a group of the formula in which latter R1represents a straight or branched alkyl group having from 1 to 6 carbon atom(s), optionally carrying a phenyl substituent, to thermic cyclization in an acidic medium. Further subject matters of the invention are [2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl]-acetonitriles or -acetic acid alkylesters of the general formula wherein R' is as defined above, useful as intermediates in the said process and a process for preparing them.