146402-89-3

Upstream product

• 3282-30-2 pivaloyl chloride 
• 17097-67-5 (4S,5S)-4-methyl-5-phenyl-oxazolidin-2-one 
• 93-25-4 2-methoxyphenylacetic acid 

Relevant academic research and scientific papers

Perhydroisoindole derivatives as substance P antagonists

New perhydroinsoindole having the general formula (I) wherein R1 is optionally substituted phenyl or is cyclohexadienyl, naphtyl, indenyl or mono or polycyclic heterocyclyl, saturated or unsaturated 5 to 9C and optionally substituted, R2 is H or halogen, OH, alkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, alkyloxycarbonyl, dialkylaminoalcyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R3 is phenyl optionally substituted in position -2 by a radical alkyl or alkyloxy 1 or 2C or by OH or F, or disubstituted by CF3, and R4 is an alkyl radical containing 1 or 2C substituted by halogen or CN, N3 or --NHCN, and the radicals R which are similar or different represent H, alkyl or phenyl, in their isomer forms having the structure (Ia) or mixtures thereof, optionally their salts when they exist and preparation thereof. The new derivatives of the invention are particularly useful as antagonists of substance P.

Perhydroisoindole derivatives, preparation thereof and pharmaceutical compositions containing same

This invention relates to perhydroisoindole derivatives of 08/448,402 formula (I), wherein radicals R are phenyl radicals optionally 2-or 3-substituted by a halogen atom or a methyl radical; R1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocyclyl; R2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; and R3 is optionally 2-substituted phenyl; optionally salts thereof where applicable; and preparation thereof. Said derivatives are particularly useful as neurokinin A antagonists. STR1

Perhydroisoindole derivatives as antagonists of substance P

This invention relates to novel perhydroisoindole derivatives of general formula (I), STR1 wherein radicals R are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical; R 1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocyclyl; R 2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; R 3 is optionally 2-substituted phenyl; R 4 is OH or fluorine when R 5 is H, or R 4 and R 5 are OH or R 4 and R 5 together form a bond; isomeric forms and mixtures thereof; optionally salts thereof where applicable; and preparation thereof. The novel derivatives are particularly useful as P substance antagonists.

Thiopyranopyrrole derivatives

This invention relates to novel derivatives of thiopyranopyrrole of general formula (I): STR1 in which R is hydrogen, allyl, or a radical having the structure: --CR a R b R c where R a and R b are hydrogen atoms or phenyl radicals optionally substituted (

Perhydroisoindole derivatives and pharmaceutical compositions containing them

This invention relates to derivatives of perhydroisoindol of formula: STR1 in which the radicals R are hydrogen atoms or together form a bond, the symbols R' are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or 3, X is an oxygen atom or an NH radical, R1 is optionally substituted phenyl, or cyclohexadienyl, naphthyl, or heterocyclyl, R2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R3 is halogen or OH and R4 is H or halogen if R3 is halogen, in their isomer forms, or mixture thereof, and possibly also their salts when they exist, and preparation thereof. The derivatives of the invention are particularly interesting as P substance antagonist.

Perhydroisoindole derivatives and preparation

This ivention relates to novel perhydroisoindole derivatives having formula (I), STR1 wherein the symbols R, which are the same or different, are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical, R'' is a phenyl radical optionally 2-substituted by a C 1-2 alkylk or alkyloxy radical, R"" is a fluorine atom or a hydroxy radical, and R''"" is a hydrogen atom, or else R'' and R''"" are hydroxy radicals, or R"" and R''"" together form a bond, and R o is a hydrogen atom or a protective radical; salts thereof whereever applicable; and preparation thereof. These products are synthetic intermediates for the preparation of derivatives having P substance antagonist activity.