1464082-68-5

Basic information

• Product Name: (±)-2-(4-nitrophenyl)-6-phenyl-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-indazol-3-ol
• Synonyms: (±)-2-(4-nitrophenyl)-6-phenyl-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-indazol-3-ol
• CAS NO: 1464082-68-5
• Molecular Weight: 499.523
• Mol File: 1464082-68-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (±)-2-(4-nitrophenyl)-6-phenyl-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-indazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-2-(4-nitrophenyl)-6-phenyl-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-indazol-3-ol(1464082-68-5)
• EPA Substance Registry System: (±)-2-(4-nitrophenyl)-6-phenyl-4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-indazol-3-ol(1464082-68-5)

Safety Data

• Hazardous Substances Data: 1464082-68-5(Hazardous Substances Data)

Upstream product

• 1251828-10-0 (±)-ethyl 2-oxo-4-phenyl-6-(3,4,5-trimethoxyphenyl)cyclohex-3-encarboxylate 
• 100-16-3 4-nitrophenylhydrazone 
• 127034-55-3 3,4,5-trimethoxychalcone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Relevant articles and documents

Design, synthesis and molecular docking study of some substituted 4,5-dihydro-2H-indazole derivatives as potential anti-inflammatory agents

A new series of 4,5-dihydro-2H-indazoles was synthesized and evaluated for anti-inflammatory activity using formalin-induced paw edema and turpentine oil-induced granuloma pouch bioassays. In addition, the inhibitory activity of cyclooxygenase, ulcerogenic effect, and acute toxicity (ALD50) values were also determined. Compounds 10, 13, 15, 16, 18 and 22 were proved to display distinctive anti-inflammatory profiles with a fast onset of action. They revealed super GI safety profile and are well tolerated by the experimental animals with high safety margin (ALD50 > 300 mg/Kg). The same active compounds exhibited moderate to powerful selectivity profile towards the inhibition of COX-2 enzyme. Docking poses for the most active compounds separately in the active site of human COX-2 enzyme were also obtained.