146446-85-7Relevant academic research and scientific papers
A novel route towards cycle-tail peptides using oxime resin: Teaching an old dog a new trick
Bérubé, Christopher,Borgia, Alexandre,Voyer, Normand
, p. 9117 - 9123 (2018)
Two anabaenopeptins, Schizopeptin 791 and anabaenopeptin NZ825, have similar structural features and have been synthesized via a novel acid-catalyzed head-to-side-chain concomitant cyclization/cleavage reaction on oxime resin. The methodology gave rapid access to the anabaenopeptin scaffold by taking advantage of a combined solid-phase/solution-phase synthetic strategy. Also, as side-products of the synthesis, large C2-symmetric 38-member cyclic peptides ring bearing two endocyclic lysine side-chains were isolated, constituting a novel cyclic peptide scaffold.
GRANZYME B DIRECTED IMAGING AND THERAPY
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Paragraph 0219-0220, (2020/08/28)
Provided herein are compounds of Formula (I) below that are useful for imaging Granzyme B. Methods of imaging Granzyme B and treating an immunoregulatory abnormality, pharmaceutical compositions, and kits comprising the Granzyme B imaging agents are also provided.
