146446-96-0

Basic information

• Product Name: 2-BENZYLPHENYL ISOCYANATE 97
• Synonyms: 2-BENZYLPHENYL ISOCYANATE 97;Benzene, 1-isocyanato-2-(phenylmethyl)- (9CI);2μ-Benzylphenyl isocyanate, 2μ-Isocyanatodiphenylmethane;1-benzyl-2-isocyanatobenzene
• CAS NO: 146446-96-0
• Molecular Formula: C₁₄H₁₁NO
• Molecular Weight: 209.24324
• Product Categories: ISOCYANATE
• Mol File: 146446-96-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 309 °C(lit.)
• Flash Point: 230 °F
• Appearance: /
• Density: 1.11 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000312mmHg at 25°C
• Refractive Index: n20/D 1.591(lit.)
• CAS DataBase Reference: 2-BENZYLPHENYL ISOCYANATE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYLPHENYL ISOCYANATE 97(146446-96-0)
• EPA Substance Registry System: 2-BENZYLPHENYL ISOCYANATE 97(146446-96-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 146446-96-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H11NO/c16-11-15-14-9-5-4-8-13(14)10-12-6-2-1-3-7-12/h1-9H,10H2

Upstream product

• 1557-41-1 N-[2-(phenylmethyl)phenyl]formamide 
• 612-35-1 2-Benzylbenzoic acid 

Downstream Products

• 1582273-47-9 phenethyl (2-benzylphenyl)carbamate 
• 1400979-93-2 4-benzyl-1-(benzyloxy)-1H-benzo[d]imidazol-2(3H)-one 
• 1581259-28-0 N-(2-benzylphenyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine-1-carboxamide 
• 1581258-95-8 N-(2-benzylphenyl)-4-(diphenylmethyl)piperazine-1-carboxamide 
• 1400979-49-8 4-benzyl-1-hydroxy-1H-benzo[d]imidazol-2(3H)-one 
• 1400979-80-7 1-(benzyloxy)-3-(2-benzylphenyl)urea 
• 1119859-68-5 3-amino-N-(2-benzylphenyl)-1H-indazole-1-carboxamide 
• 1211-06-9 5,11-dihydro-6H-dibenz[b,e]azepin-6-one 

Relevant articles and documents

Synthesis of unsymmetrical phenylurea derivatives via oxidative cross coupling of aryl formamides with amines under metal-free conditions

A new synthetic approach for phenylurea derivatives involving the cross coupling of N-aryl formamides with amines through the formation of isocyanate intermediates in the presence of hypervalent iodine reagents is described.

Selective muscarinic antagonists. II. Synthesis and antimuscarinic properties of biphenylylcarbamate derivatives

A novel series of biphenylylcarbamate derivatives were synthesized and evaluated for binding to M1, M2 and M3 receptors and for antimuscarinic activities. Receptor binding assays indicated that biphenyl-2-ylcarbamate derivatives had high affinities for M1 and M3 receptors and good selectivities for M3 receptor over M2 receptor, indicating that the biphenyl-2-yl group is a novel hydrophobic replacement for the benzhydryl group in the muscarinic antagonist field. In this series, quinuclidin-4-yl biphenyl-2-ylcarbamate monohydrochloride (81, YM-46303) exhibited the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor. Compared to oxybutynin, YM-46303 showed approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, and about 5-fold greater selectivity for urinary bladder contraction against salivary secretion in rats. Moreover, selective antagonistic activity was also observed in vitro. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, showed that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects.