1557-41-1

Basic information

• Product Name: N-(2-benzylphenyl)formamide
• CAS NO: 1557-41-1
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.2591
• Mol File: 1557-41-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 404°C at 760 mmHg
• Flash Point: 242.3°C
• Density: 1.138g/cm³
• Vapor Pressure: 9.75E-07mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: N-(2-benzylphenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-benzylphenyl)formamide(1557-41-1)
• EPA Substance Registry System: N-(2-benzylphenyl)formamide(1557-41-1)

Safety Data

• Hazardous Substances Data: 1557-41-1(Hazardous Substances Data)

Upstream product

• 372109-30-3 1-(2-benzyl-phenyl)-piperidine-2,6-dione 
• 28059-64-5 2-benzylaniline 
• 64-18-6 formic acid 
• 372109-36-9 1-(2-benzyl-phenyl)-6-hydroxy-piperidin-2-one 

Downstream Products

• 256-86-0 Morphanthridine 
• 449-55-8 6,11-dihydro-5H-dibenzo[b,e]azepine 
• 1582273-47-9 phenethyl (2-benzylphenyl)carbamate 
• 146446-96-0 1-benzyl-2-isocyanatobenzene 

Relevant articles and documents

Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: A novel series of 5-HT2A/2C receptor antagonists. Part 1

The synthesis of a series of novel 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives as well as their 5-HT2A/2C and H1 receptor binding affinities are described. The in vivo activity as potential anxiolytics of the synthesised compounds was measured in a mCPP challenge test. One of the compounds, 2a, proved to be a potent 5-HT2A/2C receptor antagonist showing as well oral activity and therefore could be considered as a potential anxiolytic/antidepressant agent.

Synthesis of tetracyclic DIBENZO[c,f]azepine and benzo[f]thieno[3,2-c]azepine derivatives via N-acyluminium ion cyclization

Tetracyclic dibenzo[c,f]-4-oxopyrrolo[1,2-c]azepine (2a), dibenzo[c,f]-5-oxopiperido[1,2-c]azepine (2b), benzo[f]-4-oxopyrrolo[1,2-a]thieno[3,2-c]azepine (2c), and benzo[f]-5-oxopiperido[1,2-a]thieno[3,2-c]azepine (2d) were prepared through intramolecular N-acyliminium ion cyclization of hydroxylactams (3a-d) with aromatic or heteroaromatic rings such as benzene and thiophene as a π-nucleophile. In the case of furan ring, the hydroxylactams (3e, f) were completely decomposed under the acidic conditions (formic acid or methanesulfonic acid). Subsequent reduction of 2a-d with BF3·O(C2H5)2 and BH3·S(CH3)2 finally provided the tetracyclic dibenzo[c,f]pyrrolo[1,2-c]azepine (1a), dibenzo[c,f]piperido[1,2-c]azepine (1b), benzo[f]pyrrolo[1,2-a]thieno[3,2-c]azepine (1c), and benzo[f]piperido[1,2-a]thieno[3,2-c]azepine derivatives (1d) as analogues of mianserin.