146471-52-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(Aminomethyl)chroman-4-ol is used as a reagent for the development of a novel class of transmission-blocking antimalarials. These antimalarial agents target male gametes, aiming to disrupt the transmission of the malaria parasite and reduce the spread of the disease. The compound's unique structure and properties make it a promising candidate for the creation of new drugs to combat malaria.

InChI:InChI=1/C10H13NO2/c11-7-10(12)5-6-13-9-4-2-1-3-8(9)10/h1-4,12H,5-7,11H2

Upstream product

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 74187-63-6 4-((trimethylsilyl)oxy)chroman-4-carbonitrile 

Relevant academic research and scientific papers

FUSED IMIDAZOLE DERIVATIVE

According to the present invention, fused imidazole derivatives of the general formula: wherein R1 is a hydrogen atom, a halogen atom, hydroxy group, a lower alkyl group or a lower alkoxy group, R2 is an aryl group, benzodioxanyl group, or 5-6 membered, monocyclic, unsaturated, heterocyclic group containing nitrogen atom(s) which may be substituted with lower alkyl, trityl or oxo, R3 is a hydrogen atom or hydroxy group, A is a group represented by the formula : -(CH2)m - or -O-(CH2)m- [wherein m is an integer of 1-3] and their salts are provided.

Serotonin Receptor Affinity of Cathinone and Related Analogues

A series of cathinone (α-aminopropiophenone) analogues was examined using the isolated rat fundus preparation. (S)-(-)-Cathinone possesses twice the serotonin receptor affinity of (+/-)-cathinone and four times the affinity of racemic amphetamine.Several derivatives of cathinone were found to either possess a lower affinity than the parent compound or did not interact with the receptors in a competitive manner.Several novel analogues, 1-(aminomethyl)-3,4-dihydronaphthalene hydrochloride (3), 4-(aminomethyl)-3-chromene hydrochloride (4b), as well as its 6-methoxy derivative, 4a, interact with serotonin receptors but in a fashion which is, most likely, dissimilar to the interaction of the substituted cathinone analogues.