146492-34-4

Upstream product

• 623-27-8 terephthalaldehyde, 
• 122-00-9 para-methylacetophenone 
• 935-14-8 1,4-diethynylbenzene 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 850408-19-4 3-{4-[4-(4-methyl-benzoyl)-2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl]-phenyl}-1-p-tolyl-propenone 
• 850408-22-9 (5-{4-[4-(4-methyl-benzoyl)-2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl]-phenyl}-1,3-diphenyl-4,5-dihydro-1H-pyrazol-4-yl)-p-tolyl-methanone 
• 850408-25-2 3-{4-[4-(4-methyl-benzoyl)-3-phenyl-4,5-dihydro-isoxazol-5-yl]-phenyl}-1-p-tolyl-propenone 
• 850408-28-5 (5-{4-[4-(4-methyl-benzoyl)-3-phenyl-4,5-dihydro-isoxazol-5-yl]-phenyl}-3-phenyl-4,5-dihydro-isoxazol-4-yl)-p-tolyl-methanone 
• 129005-92-1 1-acetyl-4,5-dihydro-5-(4-(1-acetyl-4,5-dihydro-3-(4-methylphenyl)pyrazol-5-yl)phenyl)-3-(4-methylphenyl)pyrazole 
• 1316308-23-2 diethyl 6,6'-(1,4-phenylene)bis(2-oxo-4-p-tolylcyclohex-3-enecarboxylate) 
• 1435658-12-0 diethyl 2,2′-(1,4-phenylene)bis(4,4′-p-tolylthiophene-5,5′-carboxylate) 
• 34765-70-3 1,4-bis(1-phenyl-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-5-yl)benzene 
• 138909-76-9 (4-{4-[3-(4-Methyl-benzoyl)-4,5-dihydro-1H-pyrazol-4-yl]-phenyl}-4,5-dihydro-1H-pyrazol-3-yl)-p-tolyl-methanone 

Relevant academic research and scientific papers

Antiproliferative efficacy of curcumin mimics through microtubule destabilization

Curcumin possesses an attractive chemical structure with highly conjugated diferuloylmethane core. Curcumin mimics have been designed and prepared with an additional bridged phenyl ring in conjugation. Fourteen diverse analogues were evaluated against a p

A facile synthesis of 1,4-bis-(3-Aryl-3-oxo-1-propenyl)benzenes under microwave irradiation

1,4-bis(3-Aryl-3-oxo-1-propenyl)benzenes were synthesized by 1,4-benzenedicarboxaldehyde with substituted acetophenones in the presence of sodium hydroxide under microwave irradiation with good yields.

Design, synthesis and drug resistance reversal potential of novel curcumin mimics Van D: Synergy potential of curcumin mimics

Being crucial part of plant-based novel discovery of drug from natural resources, a study was done to explore the antibacterial potential of curcumin mimics in combination with antibiotics against multidrug resistant isolates of Pseudomonas aeruginosa. Th

Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors

The chalcone and bis-chalcone derivatives have been synthesized under sonication conditions via Claisen-Schmidt condensation with KOH in ethanol at room temperature (20–89%). The structures were established on the basis of NMR, IR, Single-crystal XRD, and

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

A series of 1,4-phenylene-bis-chalcones 3a{3h were synthesized by the reaction of terephthalaldehyde with substituted arylketones in this study. The novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives 5a{5h were obtained by the addition of guanidine hy

Aluminum chloride-catalyzed C-alkylation of pyrrole and indole with chalcone and bis-chalcone derivatives

The AlCl3-catalyzed alkylation of pyrrole (2) with chalcone (1a-i) at a ratio of 8:1 in the presence of 10 mol% AlCl3 gave the solely 2-alkyl pyrroles (3a-i) at room temperature for 12 in good yields. The same reaction was performed with pyrrole (2) and chalcone at a ratio of 1:3 in CH3CN at rt for 3 h to achieve 2,5-dialkyl pyrroles (4a-f). In addition, the reaction of the pyrrole (2) and indole (7) on 1,4-phenylene bis-chalcones (5a-g) at the ratio of 8:1 at rt for 24 h gave the double-addition products 6a-g and 8a-g in good yields, respectively. The structure of the products was confirmed by 1H and 13C NMR spectroscopy and elemental analysis.

Efficient pseudo-five-component coupling-Fiesselmann synthesis of luminescent oligothiophenes and their modification

(Hetero)aryl bis-acid chlorides and terminal alkynes, or likewise acid chlorides and terminal dialkynes, and ethyl 2-mercaptoacetate can be reacted to give highly luminescent symmetrical terthiophenes and quinquethiophenes in the sense of a consecutive pseudo-five-component reaction in good to excellent yields. Further functionalization of the obtained oligomers can be readily achieved by halogenation followed by a metal-catalyzed coupling reaction to give α,ω-diester substrates for subsequent transformations into highly functionalized materials. The Royal Society of Chemistry.

Synthesis and properties of n-type triphenylpyridine derivatives and applications in deep-blue organic light-emitting devices as electron- transporting layer

Two series of n-type triphenylpyridine derivatives with good thermal properties and efficient deep-blue emissions were designed, synthesized and systematically characterized. Most of them show high glass transition temperatures (Tg > 100 °C), relatively high electron mobilities, large ionization potentials (IP > 6.31 eV) and suitable electron affinities (EA > 2.93 eV) for facilitating efficient electron-injection. These attributes of the n-type triphenylpyridine derivatives favours their applications in organic light-emitting devices (OLEDs) as electron-transporting and hole-blocking materials (ETMs and HBMs). With these new materials, deep-blue OLEDs with a configuration of indium-tin oxide (ITO)/α- napthylphenylbiphenyl diamine (NPB)/9,10-di(2-naphthyl)anthracene (ADN)/triphenylpyridine derivative/LiF/MgAg were fabricated to investigate the properties of these triphenylpyridine derivatives as ETMs and HBMs. The devices show higher efficiency (2.54 cd A-1), and better color purity (0.15, 0.10) compared to those of similarly-structured blue OLEDs using state-of-the-art ETMs. The large IP and deep-blue emission of the triphenylpyridine derivatives are considered to be key factors for the higher efficiencies and better color purity. Optical and other properties of the compounds are discussed in terms of their molecular structures.

'One-pot' ultrasound irradiation promoted synthesis and spectral characterization of an array of novel 1,1′-(5,5′-(1,4-phenylene) bis(3-aryl-1H-pyrazole-5,1(4H,5H)-diyl))diethanones, a bis acetylated pyrazoles derivatives

An array of novel 1,1′-(5,5′-(1,4-phenylene)bis(3-aryl-1H- pyrazole-5,1(4H,5H)-diyl))diethanones, a bis acetylated pyrazoles derivatives are synthesized in 'one-pot' by ultrasound irradiation method and are characterized by melting point, elemental analys

Synthesis and in vitro microbiological evaluation of novel diethyl 6,6′-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates)

Novel bis cyclohexenone ester derivatives 1419 were synthesized and characterized by their spectral data. In vitro microbiological evaluations were carried out for all the novel compounds 1419 against clinically isolated bacterial and fungal strains. Comp