1465030-91-4Relevant academic research and scientific papers
An organocatalytic highly efficient approach to the direct synthesis of substituted carbazoles in water
Jaiswal, Pradeep Kumar,Biswas, Soumen,Singh, Shivendra,Samanta, Sampak
, p. 8410 - 8418 (2013/12/04)
A simple, mild, green, catalytic and general procedure for the direct synthesis of highly functionalized 1-methoxycarbonyl-2-aryl/alkyl-3-nitro-9H- carbazoles has been achieved in water medium via a one-pot domino Michael-Henry/aromatization reaction of methyl 2-(3-formyl-1H-indol-2-yl) acetates with aryl/alky-substituted β-nitroolefins under air using DABCO (30 mol%) as an organocatalyst. In addition, the bench scale synthesis can be performed without using toxic organic solvents and a biologically important new fused carbazole has been prepared.
L-Proline catalyzed stereoselective synthesis of (E)-methyl-α-indol- 2-yl-β-aryl/alkyl acrylates: Easy access to substituted carbazoles, γ-carbolines and prenostodione
Biswas, Soumen,Jaiswal, Pradeep Kumar,Singh, Shivendra,Mobin, Shaikh M.,Samanta, Sampak
supporting information, p. 7084 - 7087 (2013/10/22)
A simple, mild and robust method for the stereoselective synthesis of (E)-methyl α-(3-formyl-1H-indol-2-yl)-β-aryl/alkyl-substituted acrylates via a condensation reaction of methyl 2-(3-formyl-1H-indol-2-yl) acetate with several alkyl or aryl aldehydes using l-proline (25 mol%) as a catalyst is presented for the first time. In addition, completely metal free based high yielding methods for the syntheses of highly substituted biologically important carbazoles, γ-carbolines and the marine alkaloid prenostodione have been developed through our methodology.
