146510-36-3 Usage
Uses
Used in Pharmaceutical Industry:
OLANEXIDINE is used as an antiseptic for skin preparation at surgical sites to reduce the risk of postoperative infections. Its application reason is its remarkable antibacterial activity against a wide range of bacterial strains, especially Gram-positive bacteria.
Used in Medical Devices Industry:
OLANEXIDINE is used in the development of medical devices that require sterilization or disinfection, such as surgical instruments and implants. Its application reason is its ability to disrupt bacterial cell membranes and denature proteins, providing effective antimicrobial protection.
Used in Research and Development:
OLANEXIDINE is used as a research compound to study its mechanism of action and potential applications in various fields, such as drug development and microbiology. Its application reason is the unique interaction with bacterial surface molecules and its ability to permeate and denature proteins at high concentrations.
Synthesis
The synthesis of olanexidine gluconate is relatively
straightforward, involving the linkage of an n-octyl side chain
and a dichlorobenzylamine through a bis-guanidyl lynchpin.
The synthesis began with the reaction of commercial noctylamine
(17) with sodium dicyanamide in the presence of
concentrated sulfuric acid in refluxing n-butyl acetate to give
rise to 1-cyano-3-octylguanidine (18) in 86% yield .
Conditions employed to subsequently secure biguanidine 20 as
the HCl salt hemihydrate in 77% yield were nearly identical to
those used for the conversion of 17 to 18. Finally, treatment of
20 with sodium hydroxide in the presence of gluconic acid (21)
gave rise to olanexidin gluconate (II) in almost quantitative
yield.
Check Digit Verification of cas no
The CAS Registry Mumber 146510-36-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,5,1 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 146510-36:
(8*1)+(7*4)+(6*6)+(5*5)+(4*1)+(3*0)+(2*3)+(1*6)=113
113 % 10 = 3
So 146510-36-3 is a valid CAS Registry Number.
146510-36-3Relevant academic research and scientific papers
Alternate synthesis of olanexidine base employing phase transfer catalysis
Khare, Lalit,Jain, Ratnesh,Dandekar, Prajakta
, (2021/11/13)
The traditional methods of synthesis of biguanide drugs generally result in the formation of high levels of waste. In this study, we have developed a simple and green route for the synthesis of olanexidine, the novel antimicrobial compound developed by Ot
METHOD AND APPARATUS FOR PREPARING A SOLUTION OF A SHEAR SENSITIVE MATERIAL
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Page/Page column 7-8, (2009/12/05)
The invention provides a novel apparatus and method for preparing a solution of a shear sensitive material.
AQUEOUS OLANEXIDINE SOLUTION, METHOD OF PREPARING THE SAME, AND DISINFECTANT
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Page/Page column 6-7; 10, (2008/06/13)
The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a
