146512-56-3

Upstream product

• 64445-78-9 (E)-2-Benzoyl-3-methylamino-3-methylsulfanyl-acrylonitrile 
• 29866-39-5 2-benzoyl-3,3-bis(methylthio)acrylonitrile 
• 109-81-9 N-methyl-ethane-1,2-diamine 
• 76182-65-5 (E)-3-Aziridin-1-yl-2-benzoyl-3-methylamino-acrylonitrile 

Relevant academic research and scientific papers

A new route to 3H-1,5-benzodiazepines and heterocyclic ketene animals from benzoyl substituted ketene dithioacetals and diamines

Heterocyclic ketene aminals 5 or 3H-1,5-benzodiazepines 4 were obtained from the reaction of benzoyl substituted ketene dithioacetals 1 with various diamines 2. The mechanism of formation of these two different products are discussed.

SYNTHESE UND REAKTIONEN NEUARTIGER N-VINYLAZIRIDINE

The ketene S,S-acetals 1 readily react with aziridine to give the corresponding 3-(1-aziridinyl)-3-methylthio-acrylnitriles 2 and 3,3-bis-(1-aziridinyl)-acrylnitriles 3.Ketene S,N-acetals 4 yield 3-anilino-3-(1-aziridinyl)-acrylnitriles 5.Reaction of 5 with potassium iodide in acetone at room temperature leads to imidazolidines 8.The isomerisation is explained in terms of a two-step mechanism.The iodide ion-catalysed rearrangement was not successful when applied to 2a.Cyclisation of 5b in the presence of sodium hydride and following hydrolysis form the tautomeric quinolone 10.On contrary to 1 and 4 mercapto ethylenes 11 and 13 with aziridine give the thiazolidine 15.