29866-39-5

Upstream product

• 98606-77-0 2-bromo-3,3-bis(methylthio)-1-phenylprop-2-en-1-one 
• 544-92-3 copper(I) cyanide 
• 13636-88-9 3,3-bis(methylthio)-1-phenylprop-2-en-1-one 
• 74-88-4 methyl iodide 

Downstream Products

• 76182-55-3 2-benzoyl-3-(1-aziridinyl)-3-methylthio-acrylnitril 
• 98190-29-5 5-Methylsulfanyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile 
• 90490-71-4 1-Methyl-3-methylsulfanyl-1-oxo-5-phenyl-1λ⁶-[1,2]thiazine-4-carbonitrile 
• 90490-77-0 4-cyano-1-methyl-3-(S,S-dimethylsulfoximido)-5-phenyl-2-azathiabenzene 1-oxide 
• 90509-83-4 C₁₄H₁₇N₃O₃S₂ 
• 87755-70-2 4-cyano-1-methyl-3-methylthio-5-phenyl-2-azathiabenzene 1-oxide 
• 35587-99-6 2-(benzoyl-cyan-methylen)-thiazolidin 
• 76732-02-0 3-Benzoyl-4-methylthio-6-phenyl-2(1H)-pyridon 
• 76742-99-9 5-Cyano-3-ethoxycarbonyl-4-methylthio-6-phenyl-2-pyron 
• 64446-14-6 2-(1,3-dihydro-benzoimidazol-2-ylidene)-3-oxo-3-phenyl-propionitrile 
• 75668-46-1 3-(2-Benzoyl-2-cyan-1-methylthiovinyl)-benzoylaceton 
• 146512-56-3 2-[1-Methyl-imidazolidin-(2E)-ylidene]-3-oxo-3-phenyl-propionitrile 
• 56434-09-4 2-benzothiazol-2-yl-3-oxo-3-phenyl-propionitrile 
• 22703-63-5 α-[bis(dimethylamino)methylene]-β-oxophenylacetonitrile 

Relevant academic research and scientific papers

S-glycosides in medicinal chemistry: Novel synthesis of cyanoethylene thioglycosides and their pyrazole derivatives

A one-pot reaction of a sodium 2-cyanoethylene-1-thiolate salt with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides affords a new class of cyanoethylene thioglycosides. The conversion to the corresponding 5-aminopyrazoles confirms the E-co

Adenosine receptor ligands and their use in the treatment of disease

The invention relates to cyclic heteroaromatic compounds, containing at least one nitrogen atom, and to their use in the manufacture of medicaments for the treatment of diseases, related to adenosine receptor modulators, such as Alzheimer's disease, Parkinson's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, asthma, allergic responses, hypoxia, ischaemia, seizure, substance abuse, sedation and they may be active as muscle relaxants, antipsychotics, anti epileptics, anticonvulsants and cardiaprotective agents.

ALKYLIERUNGS- AND ARYLIERUNGSREAKTIONEN MIT GEMINALEN DITHIOLATEN

Acyl acetonitriles 1 react with carbon disulfide in the presence of sodium hydride to give disodium salts 2.Treatment of 2 with an alkylation reagent yields the open chain or cyclic acyl cyanketene S,S-acetals 3,4,8 and 10, respectively.Arylation to 11 is successful with 2,4-dinitro-chlorobenzene.Adding only one equivalent of methyl iodide to 2 and acidifying the reaction mixture lead to the monoalkylated compounds 7, whereas β-hydroxythioanilides 12 are available by reaction of 1 with phenyl isothiocyanate.A comparison of the ?-values shows that there exists the same type of the proton's chelation of the OH-group in 7 and 12.