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Upstream product

• 619-41-0 4-(bromoacetyl)toluene 
• 75-52-5 nitromethane 
• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 106-47-8 4-chloro-aniline 
• 60532-54-9 2-[(4-chlorophenyl)amino]-1-(4-methylphenyl)ethan-1-one 

Relevant academic research and scientific papers

The solvent-free synthesis of polysubstituted pyrroles by a reusable copper Schiff base complex immobilized on silica coated Fe3O4, and DNA binding study of one resulting derivative as a potential anticancer drug

We demonstrate herein the synthesis of a new copper Schiff base complex immobilized on silica-coated Fe3O4 nanoparticles. The structure and composition of this magnetic nanocatalyst were analyzed using Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) and inductively coupled plasma atomic emission spectroscopy (ICP-AES). This nanocomposite was found to be an efficient nanocatalyst for the synthesis of polysubstituted pyrrole derivatives and the products were isolated with high turnover number (TON) and high to excellent yields. Among the new synthesized polysubstituted pyrrole derivatives, we explored the first computational and experimental binding study of methyl 1-benzyl-4-(furan-2-yl)-2-methyl-1H-pyrrole-3-carboxylate (SP-10) with calf thymus deoxyribonucleic acid (ct-DNA), suggesting their application as potential anticancer activity. In addition, the binding modes of SP-10 with DNA and human serum albumin (HSA) were verified by molecular docking technique.

An efficient and recyclable nanocatalyst for the green and rapid synthesis of biologically active polysubstituted pyrroles and 1,2,4,5-tetrasubstituted imidazole derivatives

An effective process for the green and rapid synthesis of biologically active polysubstituted pyrroles and 1,2,4,5-tetrasubstituted imidazoles derivatives using Cu@imine/Fe3O4 MNPs catalyst under solvent-free conditions is explained. This catalyst showed high reactivity for the synthesis of a set of different derivatives of polysubstituted pyrroles and 1,2,4,5-tetrasubstituted imidazole derivatives under appropriate reaction conditions and short times. Moreover, the catalyst was also recycled and reused for six runs with no considerable reduction in reactivity and yields. Compared to the reported procedures, this method consistently demonstrates the advantages of low catalyst loading, short reaction times, easy separation and purification of the products, high yields, and high recoverability and recoverability of the catalyst.

Copper Schiff base complex immobilized on silica-coated Fe3O4 nanoparticles: a recoverable and efficient catalyst for synthesis of polysubstituted pyrroles

In this work, a copper Schiff base complex immobilized on silica-coated Fe3O4 nanoparticles is synthesized, and studied as a highly efficient, recyclable, green and heterogeneous catalyst for the preparation of polysubstituted pyrroles under solvent-free and mild conditions. This new catalyst was characterized by different techniques, such as Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), field-emission scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), inductively coupled plasma (ICP) and vibrating sample magnetometry (VSM). The simple and environmentally one-pot multicomponent condensation of nitromethane, an aryl aldehyde, a 1,3-dicarbonyl compound and an amine in the presence of above catalyst affords the title compounds at room temperature. At the end, we compared the results for the synthesis of polysubstituted pyrroles in the presence of our nanocatalyst with previously reported catalysts in the literature.

Research on antibacterial and antifungal agents. VIII. Synthesis and antimicrobial activity of 1,4-diarylpyrroles

The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against