146548-65-4

Upstream product

• 101-02-0 triphenyl phosphite 
• 3598-60-5 4-phthalimidobutanal 
• 32464-55-4 2-(4,4-diethoxybutyl)isoindoline-1,3-dione 
• 85-44-9 phthalic anhydride 
• 149194-43-4 diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate 

Downstream Products

• 146548-64-3 [1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester 
• 146548-70-1 (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid diphenyl ester; hydrochloride 
• 146548-67-6 (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-amino-butyl)-phosphonic acid diphenyl ester; hydrochloride 

Relevant academic research and scientific papers

A convenient synthesis of N-protected diphenyl phosphonate ester analogues of ornithine, lysine and homolysine

A 3-step synthesis to the title compounds has been developed which provides them differentially protected at nitrogen. These could then be selectively deprotected using hydrazine hydrate or hydrogenolysis over Pd/C.

Synthesis of Phosphonopeptides as Thrombin Inhibitors

Synthesis of phosphonopeptides 1 and their inhibitory activity of thrombin are described.