146557-87-1Relevant articles and documents
Synthesis of thymidine dimer derivatives containing an amide linkage and their incorporation into oligodeoxyribonucleotides
Lebreton, Jacques,De Mesmaeker, Alain,Waldner, Adrian,Fritsch, Valerie,Wolf, Romain M.,Freier, Susan M.
, p. 6383 - 6386 (1993)
The syntheses of thymidine dimers in which the natural phosphodiester linkage has been replaced by an amide group (3′-NR-CO-CH2-5′; R=H, Me, n-Pr) are described. These new dimers were incorporated into oligonucleotides. Measurement of melting temperatures (Tm of DNA/RNA duplexes and the nuclease resistance are presented. Preliminary results of molecular mechanics calculations are included.