146557-91-7

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 146557-86-0 3-[(2R,3S,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propionic acid methyl ester 
• 146557-87-1 3-[(2R,3S,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propionic acid 
• 146604-43-5 1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil 
• 123556-91-2 5'-O-thexyldimethylsilyl-3'-amino-3'-deoxythymidine 

Relevant academic research and scientific papers

Synthesis of thymidine dimer derivatives containing an amide linkage and their incorporation into oligodeoxyribonucleotides

The syntheses of thymidine dimers in which the natural phosphodiester linkage has been replaced by an amide group (3′-NR-CO-CH2-5′; R=H, Me, n-Pr) are described. These new dimers were incorporated into oligonucleotides. Measurement of melting temperatures (Tm of DNA/RNA duplexes and the nuclease resistance are presented. Preliminary results of molecular mechanics calculations are included.