146560-44-3Relevant academic research and scientific papers
Stereoselective synthesis of enantiopure 4,5-disubstituted pyrrolidin-2-ones by consecutive cuprate addition and N-acyliminium coupling
Koot, Wim-Jan,Hiemstra, Henk,Speckamp, W. Nico
, p. 7969 - 7972 (1992)
The enantiopure γ-lactam (R)-1-acetyl-5-isopropoxy-3-pyrrolin-2-one (1), prepared from (S)-malic acid, undergoes cuprate addition at C4 with complete trans-stereoselectivity. The products react with π-nucleophiles in the presence of Lewis acid at C5 to provide enantiopure, 4,5-disubstituted pyrrolidin-2-ones.
