1465740-83-3Relevant academic research and scientific papers
Efficient synthesis of quinoxalines with hypervalent iodine as a catalyst
Chen, Chung-Yu,Hu, Wan-Ping,Liu, Mei-Chun,Yan, Pi-Cheng,Wang, Jeh-Jeng,Chung, Mei-Ing
, p. 9735 - 9741 (2013/10/22)
Various biologically important quinoxalines were efficiently synthesized in excellent yields via one-pot reaction between 1,2-diaminobenzenes and internal alkynes. The method utilizes inexpensive and readily available hypervalent iodine source, such as (diacetoxyiodo)benzene (PhI(OAc)2) and proved to be a better alternative as compared to expensive transition metal catalysts. Quinoxaline 4i [(2-phenyl-3-(3,4,5-trimethoxy phenyl)quinoxaline)] was evaluated for leukemia cancer cell lines and turned out to be a good candidate.
