146579-90-0Relevant academic research and scientific papers
One-pot preparation of chiral beta-amino esters by rhodium-catalyzed three-components coupling reaction.
Honda, Toshio,Wakabayashi, Hitoshi,Kanai, Kazuo
, p. 307 - 308 (2007/10/03)
Chiral beta-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatsky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imines prepared in
An Efficient Enantiomeric Three Step Synthesis of β-Amino Acids (Esters)
Mokhallalati, Mohamed K.,Wu, Ming-Jung,Pridgen, Lendon N.
, p. 47 - 50 (2007/10/02)
Ethyl tributylstannylacetate was reacted with (R)-2-aryl or alkyl-1,3-oxazolidines 6 under very specific (ZnCl2/Et2O*BF3, 0.5 equiv each) Lewis Acid catalyzed conditions to yield (1R,1'R)-N-2'-hydroxy-1'-phenylethyl-1-aryl or alkyl-2-carboethoxyethylamine
