1466514-72-6

Basic information

• Product Name: 2-amino-5-bromo-4-chloropyridine-3-carbaldehyde
• Synonyms: 2-amino-5-bromo-4-chloropyridine-3-carbaldehyde
• CAS NO: 1466514-72-6
• Molecular Weight: 235.468
• Mol File: 1466514-72-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-amino-5-bromo-4-chloropyridine-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-bromo-4-chloropyridine-3-carbaldehyde(1466514-72-6)
• EPA Substance Registry System: 2-amino-5-bromo-4-chloropyridine-3-carbaldehyde(1466514-72-6)

Safety Data

• Hazardous Substances Data: 1466514-72-6(Hazardous Substances Data)

Upstream product

• 868736-42-9 tert-butyl N-(4-chloro-3-formylpyridin-2-yl)carbamate 
• 130721-78-7 tert-butyl (4-chloropyridin-2-yl) carbamate 
• 19798-80-2 2-Amino-4-chloropyridine 
• 884004-48-2 2-amino-4-chloronicotinaldehyde 

Downstream Products

• 1466514-96-4 C₂₀H₁₇ClN₄O₅ 
• 1466514-32-8 C₂₄H₂₃ClFN₅O₄ 
• 1466514-55-5 C₂₅H₂₃FN₆O₄ 
• 1466514-37-3 C₂₈H₂₇ClFN₇O₄ 
• 1466514-90-8 C₂₂H₁₉BrCl₂N₄O₃ 
• 1466514-91-9 C₂₆H₂₇BrClN₅O₃ 
• 1466514-29-3 C₂₆H₂₆ClN₅O₃ 
• 1466514-94-2 C₂₂H₂₀BrCl₂N₃O₄ 
• 1466514-95-3 C₂₉H₃₃ClN₄O₇ 

Relevant articles and documents

Fused ring compounds as FGFR4 inhibitors

The heart toxicity is low. High selectivity as FGFR4 inhibitor fused ring compounds, pharmaceutical compositions containing said compounds, useful intermediates and for preparing said compounds, and methods of treating cell proliferative diseases such as cancer using the compounds of the present invention.

INHIBITORS OF BRUTON'S TYROSINE KINASE

The present invention relates to a new compound of formula I: or pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein: V1 is C or N, V2 is C(R2) or N, whereby if V1 is C then V2 is N, if V1 is C then V2 is C(R2), or if V1 is N then V2 is C(R2); each n, k is independently 0, 1; each R2, R11 is independently H, D, Hal, CN, NR'R", C(O)NR'R", C1-C6 alkoxy; R3 is H, D, hydroxy, C(O)C1-C6 alkyl, C(O)C2-C6 alkenyl, C(O)C2-C6 alkynyl, C1-C6 alkyl; R4 is H, Hal, CN, CONR'R", hydroxy, C1-C6 alkyl, C1-C6 alkoxy; L is CH2, NH, O or chemical bond; R1 is selected from the group of the fragments, comprising: Fragment 1, Fragment 2, Fragment 3 each A1, A2, A3, A4 is independently CH, N, CHal; each A5, A6, A7, A8, A9 is independently C, CH or N; R5 is H, CN, Hal, CONR'R", C1-C6 alkyl, non-substituted or substituted by one or more halogens; each R' and R" is independently selected from the group, comprising H, C1-C6 alkyl, C1-C6 cycloalkyl, aryl; R6 is selected from the group: [formula II] each R7, R8, R9, R10 is independently vinyl, methylacetylenyl; Hal is CI, Br, I, F, which have properties of inhibitor of Bruton's tyrosine kinase (Btk), to pharmaceutical compositions containing such compounds, and their use as pharmaceuticals for treatment of diseases and disorder.

NAPHTHYRIDINONE DERIVATIVES AS INHIBITORS OF CYTOMEGALOVIRUS DNA POLYMERASE

Compounds of Formula (I) wherein n, m, R1, R2, R3, R4, R5 and R6 are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.