146659-61-2

Basic information

• Product Name: (E)-N'-(2-hydroxybenzylidene)isobutyrohydrazide
• Synonyms: (E)-N'-(2-hydroxybenzylidene)isobutyrohydrazide
• CAS NO: 146659-61-2
• Molecular Weight: 206.244
• Mol File: 146659-61-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N'-(2-hydroxybenzylidene)isobutyrohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N'-(2-hydroxybenzylidene)isobutyrohydrazide(146659-61-2)
• EPA Substance Registry System: (E)-N'-(2-hydroxybenzylidene)isobutyrohydrazide(146659-61-2)

Safety Data

• Hazardous Substances Data: 146659-61-2(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 3619-17-8 isobutyric acid hydrazide 

Downstream Products

• 53067-93-9 2-isobutyrylbenzaldehyde 

Relevant articles and documents

Phthalides by rhodium-catalyzed ketone hydroacylation

(Chemical Equation Presented) Phthalides are biologically relevant five-membered lactones found in herbs, fruits, and vegetables. Herein we communicate the first atom-economical approach to phthalides by using enantioselective ketone hydroacylation. In the presence of Rh[(Duanphos)]X (X = NO3, OTf, OMs), various 2-ketobenzaldehydes undergo intramolecular hydroacylation to produce phthalide products in good yields and 92-98% ee's. Our study highlights the key role counterions play in controlling both reactivity and enantioselectivity. A concise asymmetric total synthesis of the celery extract (S)-(-)-3-n-butylphthalide is also presented.