3619-17-8

Basic information

• Product Name: Isobutyric acid hydrazide
• Synonyms: 2-methylpropionicacidhydrazide;isobutyrylhydrazide;CHEMBRDG-BB 3015435;ISOBUTYROHYDRAZIDE;ISOBUTYRIC ACID HYDRAZIDE;ART-CHEM-BB B015435;AKOS B015435;SPECS AE-848/30741004
• CAS NO: 3619-17-8
• Molecular Formula: C₄H₁₀N₂O
• Molecular Weight: 102.14
• Product Categories: API intermediates
• Mol File: 3619-17-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 97 °C
• Boiling Point: 238.63 °C at 760 mmHg
• Flash Point: 98.12 °C
• Appearance: /
• Density: 0.977 g/cm³
• Vapor Pressure: 0.042mmHg at 25°C
• Refractive Index: 1.442
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: soluble in Methanol
• PKA: 13.46±0.36(Predicted)
• CAS DataBase Reference: Isobutyric acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Isobutyric acid hydrazide(3619-17-8)
• EPA Substance Registry System: Isobutyric acid hydrazide(3619-17-8)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38-25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 3619-17-8(Hazardous Substances Data)

Usage

General Description

Isobutyric acid hydrazide, also known as 2-methylpropanohydrazide, is a chemical compound with the molecular formula C4H10N2O. It is a hydrazide derivative of isobutyric acid and is commonly used as a chemical intermediate in organic synthesis. Isobutyric acid hydrazide is a white to off-white crystalline solid with a slightly amine-like odor. It is commonly used in the production of pharmaceuticals, as well as in the synthesis of various organic compounds. Isobutyric acid hydrazide is also used as a corrosion inhibitor in some industrial applications. Additionally, it is also utilized in the manufacturing of agricultural chemicals and as a reagent in some analytical and biochemical processes.

InChI:InChI=1/C4H10N2O/c1-3(2)4(7)6-5/h3H,5H2,1-2H3,(H,6,7)

Upstream product

• 97-62-1 Ethyl isobutyrate 
• 79-31-2 isobutyric Acid 
• 79-30-1 isobutyryl chloride 
• 547-63-7 Methyl isobutyrate 
• 1523-69-9 diethyl isobutyryl phosphonate 
• 2388-01-4 methacryloyl hydrazide 
• 563-83-7 ISOPROPYLAMIDE 

Downstream Products

• 121936-73-0 isobutyric acid-(1-methyl-2-oxo-propylidenehydrazide) 
• 25996-87-6 Isobutyric acid [1-(4-chloro-phenyl)-eth-(Z)-ylidene]-hydrazide 
• 25996-49-0 Isobutyric acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 1711-88-2 5-isopropyl-3H-[1,3,4]oxadiazol-2-one 
• 65283-97-8 5-isopropyl-1,3,4-oxadiazol-2-amine 
• 25996-50-3 C₁₂H₁₃N₃O 
• 25996-45-6 Isobutyric acid [1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazide 
• 42596-43-0 Isobutyric acid [1-(2,6-dichloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 124614-79-5 1-(2-methylpropanoyl)-2-(3-methyl-2-butylidene)hydrazine 
• 133662-15-4 Isobutyric acid [1-(2-chloro-phenyl)-eth-(E)-ylidene]-hydrazide 
• 120571-99-5 N-[(E)-1-(3-Isopropyl-[1,2,4]triazolo[4,3-c]quinazolin-5-yl)-2-(4-methoxy-phenyl)-vinyl]-benzamide 
• 120571-94-0 2-Chloro-N-[(E)-1-[2-(N'-isobutyryl-hydrazinocarbonyl)-phenylcarbamoyl]-2-(4-methoxy-phenyl)-vinyl]-benzamide 
• 128153-96-8 Isobutyric acid [1-(2,4-dichloro-phenyl)-eth-(E)-ylidene]-hydrazide 
• 138211-87-7 N-isobutyryl-N'-phenylacetylhydrazine 

Relevant articles and documents

Synthetic method of 1,3,4-thiadiazole derivative

The invention discloses a synthetic method of a 1,3,4-thiadiazole derivative. The method comprises the following steps: (1) using hydrazine hydrate as a raw material, under the action of a catalyst, reacting with acid, to obtain a hydrazide compound I; (2) using alkyl chloroformate and thiocyanate to react in a condition of a solvent, to obtain an isothiocyanate compound II; (3) in a reaction system of the isothiocyanate compound II, adding solution containing the compound I, reacting to obtain solution containing a compound III; (4) processing the solution of the compound III by dehydrating,neutralizing, and washing, to obtain a compound IV; (5) in the conditions of an acid-binding agent and a solvent, adding alkyl halide or sulfuric acid diester into the compound IV, reacting to obtaina compound V; and (6) enabling the compound V to perform an amination reaction with primary amine, to obtain the 1,3,4-thiadiazole derivative VI. The preparation method has the advantages of green andno pollution, simple and convenient operation, higher yield, mild reaction condition and the like.

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