146679-28-9

Upstream product

• 100-46-9 benzylamine 
• 146679-25-6 (R)-N-benzyl-3-hydroxybutyramide 

Downstream Products

• 933775-39-4 2-[3-(benzyl-tert-butoxycarbonyl-amino)-1-methyl-propyl]-2-(3-oxo-butyrylamino)-malonic acid diethyl ester 
• 933775-38-3 (S)-2-amino-2-[3-(benzyl-tert-butoxycarbonylamino)-1-methylpropyl]-malonic acid diethyl ester 
• 933775-41-8 [3-(4-acetyl-3,5-dioxo-pyrrolidin-2-yl)-butyl]-benzyl-carbamic acid tert-butyl ester 
• 933775-37-2 (S)-2-[3-(benzyl-tert-butoxycarbonylamino)-1-methylpropyl]-malonic acid diethyl ester 
• 933775-35-0 2-(3-benzylamino-1-methyl-propyl)-malonic acid diethyl ester 
• 933775-49-6 3-acetyl-5-(3-benzylamino-1-methyl-propyl)-pyrrolidine-2,4-dione 
• 933775-42-9 (7S,7aR)-3-acetyl-4-benzyl-7-methyl-1,4,5,6,7,7a-hexahydropyrrolo(3,2-b)-pyridin-2-one 
• 933775-26-9 (R)-3-benzyl-6-methyl-[1,2,3]-oxathiazinane-2,2-dioxide 
• 933775-47-4 3-benzyl-6-methyl-[1,2,3]oxathiazinane 2-oxide 

Relevant academic research and scientific papers

Enzymatic Synthesis of 3-Hydroxybutyramides and their Conversion to Optically Active 1,3-Aminoalcohols

3-Hydroxybutyramides are obtained in high optical yield from ethyl (+/-)-3-hydroxybutyrate and aliphatic amines when the reaction is catalyzed by Candida antarctica lipase.The chemical reduction of these 3-hydroxybutyramides yields the corresponding 1,3-a

Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin

Short and efficient enantioselective syntheses of (-)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates. The Royal Society of Chemistry.

Practical Enzymatic Route to Optically Active 3-Hydroxyamides. Synthesis of 1,3-Aminoalcohols

Candida antarctica lipase (CAL) is a very efficient catalyst for the enantioselective aminolysis of different racemic 3-hydroxyesters with aliphatic amines.The degree of enantioselectivity exhibited by the lipase depends on the substrate and nucleophile, but in the most cases, the E values obtained are very satisfactory.CAL also catalyzes the aminolysis of ethyl (+/-)-3,4-epoxybutyrate and the epoxyamide was achieved with high e. e.The chemical reduction of the 3-hydroxyamides obtained by enzymatic aminolysis yields the corresponding 1,3-aminoalcohols.