146680-56-0

Basic information

• Product Name: 1,3-bis(4-fluorophenyl)-2-thioxoimidazolidine-4,5-dione
• Synonyms: 1,3-bis(4-fluorophenyl)-2-thioxoimidazolidine-4,5-dione
• CAS NO: 146680-56-0
• Molecular Formula: C₁₅H₈F₂N₂O₂S
• Molecular Weight: 318.2980264
• Mol File: 146680-56-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-bis(4-fluorophenyl)-2-thioxoimidazolidine-4,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(4-fluorophenyl)-2-thioxoimidazolidine-4,5-dione(146680-56-0)
• EPA Substance Registry System: 1,3-bis(4-fluorophenyl)-2-thioxoimidazolidine-4,5-dione(146680-56-0)

Safety Data

• Hazardous Substances Data: 146680-56-0(Hazardous Substances Data)

Usage

Class

Benzamide derivatives

Function

Antipsychotic medication

Mechanism of action

Blocks dopamine receptors in the brain

Primary use

Treatment of schizophrenia

Additional use

Managing agitation and aggression in patients with dementia

Administration

Typically oral

Side effect profile

Relatively low risk of causing extrapyramidal side effects compared to other antipsychotic medications

Precaution

Potential side effects, should be used under the guidance of a healthcare professional

Upstream product

• 79-37-8 oxalyl dichloride 
• 404-52-4 N,N’-di-(4-fluorophenyl)thiourea 
• 20033-74-3 bis(phenylimidoyl)chloride 

Relevant articles and documents

Reactivity of fluoro-substituted bis(thiocarbonyl) donors with diiodine: An XRD, FT-Raman, and DFT investigation

The reactions of 1,3,8,10-tetrakis(4′-fluorophenyl)-4,5,6,7- tetrathiocino[1,2-b:3,4-b′]diimidazolyl-2,9-dithione (4) and molecular diiodine afforded spoke adducts with stoichiometries 4·I2 and 4×3I2, isolated in the compound 4·3I2· xCH2Cl2·(1-x)I2 (x=0.70), and characterized by single-crystal XRD and FT-Raman spectroscopy. The nature of the reaction products was investigated under the prism of theoretical calculations carried out at the DFT level. The structural data, FT-Raman spectroscopy, and quantum mechanical calculations agree in indicating that the introduction of fluorophenyl substituents results in a lowering of the Lewis basicity of this class of bis(thiocarbonyl) donors compared with alkyl-substituted tetrathiocino donors and fluorine allows for extended interactions that are responsible for solid-state crystal packing. Copyright