14670-03-2

Basic information

• Product Name: Benzenemethanol, 4-methoxy-, 4-methylbenzenesulfonate
• CAS NO: 14670-03-2
• Molecular Formula: C15H16O4S
• Molecular Weight: 292.356
• Mol File: 14670-03-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-methoxy-, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-methoxy-, 4-methylbenzenesulfonate(14670-03-2)
• EPA Substance Registry System: Benzenemethanol, 4-methoxy-, 4-methylbenzenesulfonate(14670-03-2)

Safety Data

• Hazardous Substances Data: 14670-03-2(Hazardous Substances Data)

Usage

Structure

It consists of a benzenemethanol molecule with a 4-methoxy group (CH3O-) and a 4-methylbenzenesulfonate group (-SO3CH3) attached to it.

Common Uses

Pharmaceutical Industry: Used as a precursor in the synthesis of various drugs and pharmaceutical products.
Organic Synthesis: Acts as a starting material for the synthesis of other organic chemicals and as an intermediate in the production of aromatic compounds.

Role in Chemical Research

Reagent: Important for its role as a reagent in organic synthesis and chemical research.

Versatility

Valuable building block for the synthesis of a wide range of organic molecules.

Applications

Widely used in pharmaceutical, agrochemical, and material science industries for diverse applications.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 105-13-5 4-Methoxybenzyl alcohol 
• 4124-41-8 p-toluenesulfonylanhydride 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 128773-74-0 1-(4-methoxybenzyl)-5,6-dihydropyridin-2(1H)-one 
• 128773-77-3 1-(4-Methoxy-benzyl)-3-phenylselanyl-piperidin-2-one 
• 128773-76-2 2-(p-methoxbenzyl)-1,2,3,4-tetrahydro-5,11-dimethylpyrido<4,3-b>carbazole 
• 128773-75-1 2-(p-methoxybenzyl)-3,4-dihydro-5,11-dimethyl-1-oxopyrido<4,3-b>carbazole 
• 1138320-48-5 N'-(3-nitrophenyl)hydrazinecarbodithioic acid 4-methoxybenzyl ester 
• 7577-09-5 1-(cyclohex-1-en-1-ylmethyl)-4-methoxybenzene 
• 128773-73-9 N-(4-Methoxybenzyl)-δ-valerolactam 

Relevant articles and documents

Chemoselective and scalable preparation of alkyl tosylates under solvent-free conditions

The improved method for the efficient tosylation of alcohols has been reported using two procedures (A and B). Procedure A: methanol, ethanol, benzyl alcohols, and valuable ethylene glycols can be converted into their corresponding alkyl tosylates in very fast, simple, and efficient grinding method using potassium carbonate as solid base. Other primary and secondary alcohols need to add potassium hydroxide to reaction mixture (procedure B). High selectivity of tosylation was observed for these two procedures. Scale up ability was found in this method even in 100 mmol of substrate. The present method is the example of solid-state tosylation using tosyl chloride, and is a green chemical process due to solvent-free conditions.

Cobalt(II) catalyzed tosylation of alcohols with p-toluenesulfonic acid

Cobalt(II) chloride hexahydrate (CoCl2·6H2O) has been found to catalyze the tosylation of both aliphatic and aromatic alcohols with p-toluenesulfonic acid (p-TsOH) in high yields in 1,2-dichloroethane under reflux (ca. 80°C). In the