128773-73-9

Basic information

• Product Name: 1-(4-METHOXY-BENZYL)-PIPERIDIN-2-ONE
• Synonyms: 1-(4-METHOXY-BENZYL)-PIPERIDIN-2-ONE
• CAS NO: 128773-73-9
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.27958
• Mol File: 128773-73-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 396.627°C at 760 mmHg
• Flash Point: 193.673°C
• Appearance: /
• Density: 1.117g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(4-METHOXY-BENZYL)-PIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-BENZYL)-PIPERIDIN-2-ONE(128773-73-9)
• EPA Substance Registry System: 1-(4-METHOXY-BENZYL)-PIPERIDIN-2-ONE(128773-73-9)

Safety Data

• Hazardous Substances Data: 128773-73-9(Hazardous Substances Data)

Usage

General Description

1-(4-METHOXY-BENZYL)-PIPERIDIN-2-ONE is a chemical compound with the molecular formula C14H19NO2. It is a piperidinone derivative, which is a class of compounds commonly used in pharmaceutical research. This specific compound contains a piperidine ring with a methoxybenzyl group attached to it. It may have potential applications in medicinal chemistry, particularly in the development of new drugs and therapeutic agents. The compound's structure and properties make it a potentially valuable building block for the synthesis of various pharmaceuticals and research chemicals. Further study and experimentation may reveal its potential uses in drug discovery and development.

InChI:InChI=1/C13H17NO2/c1-16-12-7-5-11(6-8-12)10-14-9-3-2-4-13(14)15/h5-8H,2-4,9-10H2,1H3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 660-88-8 5-aminopentanoic acid 
• 110-89-4 piperidine 
• 824-94-2 p-methoxybenzyl chloride 
• 46441-11-6 1-(4-methoxy-benzyl)-piperidine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 675-20-7 piperidin-2-one 
• 14670-03-2 p-methoxybenzyl tosylate 

Downstream Products

• 1215765-60-8 1-(4-methoxybenzyl)-3,3-bis(3-methylbut-2-enyl)piperidin-2-one 
• 3768-43-2 3-methyl-piperidin-2-one 
• 1359020-81-7 diethyl 1-(4-methoxybenzyl)-2-oxopiperidin-3-ylphosphonate 

Relevant articles and documents

Synthesis of Lactams by Reductive Amination of Carbonyl Derivatives with ω-Amino Fatty Acids under Hydrosilylation Conditions

An efficient method for the preparation of lactams from ω-amino fatty acids under hydrosilylation is described. A variety of lactams such as pyrrolidinones, piperidinones and 2-azepanones were selectively synthesised in moderate to excellent yields (29 examples, up to 95 % isolated yields) with a good functional group tolerance. Notably, no metallic based catalyst was required to perform this transformation.

Transition-Metal-Free Amine Oxidation: A Chemoselective Strategy for the Late-Stage Formation of Lactams

A metal-free strategy for the formation of lactams via selective oxidation of cyclic secondary and tertiary amines is described. Molecular iodine facilitates both chemoselective and regioselective oxidation of C-H bonds directly adjacent to a cyclic amine. The mild conditions, functional group tolerance, and substrate scope are demonstrated using a suite of diverse small molecule cyclic amines, including clinically approved drug scaffolds.

Photochemical rearrangement of N -chlorolactams: A route to N -heterocycles through concerted ring contraction

We report a novel ring contraction allowing the direct conversion of N-chlorolactams to their corresponding ring-contraction N-heterocycles upon photolysis. Results show that the rearrangement occurs with a variety of N-chlorolactams and that the greater the substitution at the migrating carbon, the greater the yield of product. Importantly, stereochemistry at the migrating carbon is conserved in the product. Rearranged products were isolated as their methyl carbamates in yields varying from 17% to 58%, with the major side product being the recyclable parent lactam.