1467092-63-2

Upstream product

• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 1259283-28-7 ent-tubuphenylalanine hydrochloride 
• 1467092-21-2 (2R,4S)-methyl 4-amino-2-methyl-5-phenylpentanoate hydrochloride 
• 1467092-27-8 ethyl 2-((1S,3S)-3-((2S,3S)-2-((tert-butoxycarbonyl)amino)-3-methylpentanamido)-1-hydroxy-4-methylpentyl)thiazole-4-carboxylate 
• 1467092-42-7 (2R,4S)-methyl 4-(2-((1R,3S)-3-((2S,3S)-2-((tert-butoxycarbonyl)amino)-3-methylpentanamido)-1-hydroxy-4-methylpentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate 
• 944559-47-1 2-(3-tert-butoxycarbonylamino-4-methylpentanoyl)thiazole-4-carboxylic acid ethyl ester 
• 160060-21-9 2-acetylthiazol-4-carboxylic acid ethyl ester 
• 41447-17-0 (R)-1-methylpiperidine-2-carboxylic acid 

Downstream Products

• 1467091-99-1 (2R,4S)-4-(2-((1R,3S)-1-acetoxy-4-methyl-3-((2S,3S)-3-methyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoic acid 

Relevant academic research and scientific papers

Synthesis and cytotoxicity evaluation of diastereoisomers and N-terminal analogues of tubulysin-U

Tubulysins are potent anti-mitotic natural compounds and a scalable and efficient synthetic route for generation of its analogues has been developed and extended to the synthesis of diastereoisomers and N-terminal analogues of tubulysin-U. Structure-activ