146725-29-3Relevant academic research and scientific papers
Solvent-free condensation of arylacetonitrile with aldehydes
Guillot, Régis,Loupy, André,Meddour, Abdelkrim,Pellet, Michèle,Petit, Alain
, p. 10129 - 10137 (2005)
The condensation of a series of arylacetonitriles with aldehydes can be carried out by mixing equivalent amounts of reagents with neat powdered KOH at room temperature for 3-60 min depending on the aldehyde steric hindrance. At higher temperature (110°C), yields were generally higher and purity increased within very short reaction times (1-5 min). With pentamethylphenylacetonitrile, a phase transfer agent was necessary to give a satisfactory yield.
Second-Order Optical Nonlinearities of Substituted Stilbenes and the Related Compounds Containing a Trifluoromethyl as the Electron-Withdrawing Group
Sugiyama, Yoshio,Suzuki, Yasushi,Mitamura, Shuichi,Nishiyama, Tatsuo
, p. 687 - 691 (1993)
The second-order optical nonlinearities and transparencies of seventeen 4,4'-disubstituted stilbenes and ten related compounds containing a trifluoromethyl group at the para position, as the electron-withdrawing group, were examined.The introduction of a
Regioselective preparation of 2-substituted 3,4-diaryl pyrroles: A concise total synthesis of ningalin B
Bullington, James L.,Wolff, Russell R.,Jackson, Paul F.
, p. 9439 - 9442 (2007/10/03)
Methylisocyanoacetate undergoes a 2 + 3 cycloaddition with α,β-unsaturated nitriles to provide a regioselective synthesis of 2-substituted 3,4-diaryl pyrroles. The ease of preparation of α,β-unsaturated nitriles allows the rapid synthesis of pyrroles with varied substituents. Using this method, a key intermediate (1) for the synthesis of the marine natural products lukianol A, lamellarin O, and lamellarin Q was prepared in two steps. A total synthesis of ningalin B (11) was also accomplished utilizing this methodology.
